Cold agglutinin disease

Cold agglutinin disease is a type of autoimmune hemolytic anemia (see this term) defined by the presence of cold autoantibodies (autoantibodies which are active at temperatures below 30°C).

Cryoglobulinemia

Increased level of cryoglobulins in the blood. Cryoglobulins are abnormal immunoglobulins, especially IGG or IGM, that precipitate spontaneously when serum is cooled below 37 degrees Celsius.


Total: 5

                       


(per page)
PMID (PMCID)
26002963
 MALE Adult
How I treat Waldenstrom macroglobulinemia.
Treon SP.
Blood. 2015;126(6):721-32.
Patients with disease-related hemoglobin <10 g/L, platelets <100 10(9)/L, bulky adenopathy and/or organomegaly, symptomatic hyperviscosity, peripheral neuropathy, amyloidosis, cryoglobulinemia, cold-agglutinin disease, or transformed disease should be considered for therapy.
19097173
 MALE Middle Aged
Catastrophic multiple organ ischemia due to an anti-Pr cold agglutinin developing in a patient with mixed cryoglobulinemia after treatment with rituximab.
Ruch J, McMahon B, Ramsey G, Kwaan HC.
Am J Hematol. 2009;84(2):120-2.
Unlike previous reports of patients with cryoglobulinemia and cold agglutinin disease, our patient did not have a detectable cryoprecipitate when his cold agglutinin manifested.
19097173
 MALE Middle Aged
Catastrophic multiple organ ischemia due to an anti-Pr cold agglutinin developing in a patient with mixed cryoglobulinemia after treatment with rituximab.
Ruch J, McMahon B, Ramsey G, Kwaan HC.
Am J Hematol. 2009;84(2):120-2.
Cold agglutinin disease occurring with cryoglobulinemia is a rare occurrence.
15495242
 MALE Adult
Rituximab for refractory Evans syndrome and other immune-mediated hematologic diseases.
Mantadakis E, Danilatou V, Stiakaki E, Kalmanti M.
Am J Hematol. 2004;77(3):303-10.
Rituximab appears safe and modestly effective in a variety of immune-mediated hematologic diseases, including autoimmune hemolytic anemia, chronic immune thrombocytopenia, Evans syndrome, pure red cell aplasia, mixed type II cryoglobulinemia, cold agglutinin disease, and Waldenstrom's macroglobulinemia.
10342051
 MALE
Severe cold agglutinin disease and cryoglobulinemia secondary to a monoclonal anti-Pr2 IgM lambda cryoagglutinin.
Ciejka JZ, Cook EB, Lawler D, Martin J, Woodson RD, Graziano F.
Clin Exp Rheumatol. 1999;17(2):227-31.
To present a case of cold agglutinin disease/cryoglobulinemia secondary to a monoclonal anti-Pr2 IgM lambda antibody, and review the literature on the occurrence of this antibody in cold-induced disease and the clinical disease associated with it.