Cystic fibrosis

Cystic fibrosis (CF) is a genetic disorder characterized by the production of sweat with a high salt content and mucus secretions with an abnormal viscosity.

Ataxia

Cerebellar ataxia refers to ataxia due to dysfunction of the cerebellum. This causes a variety of elementary neurological deficits including asynergy (lack of coordination between muscles, limbs and joints), dysmetria (lack of ability to judge distances that can lead to under- oder overshoot in grasping movements), and dysdiadochokinesia (inability to perform rapid movements requiring antagonizing muscle groups to be switched on and off repeatedly).


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(per page)
PMID (PMCID)
2599500
 MALE Adult
[Isolated vitamin E deficiency].
Trabert W, Stober T, Mielke U, Heck FS, Schimrigk K.
Fortschr Neurol Psychiatr. 1989;57(11):495-501.
Such a deficiency can be found mostly in a disturbed resorption or transport of the vitamin (mucoviscidosis, chronic cholestasis, abetalipoproteinaemia) and leads typically to a progredient spinocerebellar ataxia in combination with a polyneuropathy.
6732199
 FEMALE Adult
Reversible visual evoked potential abnormalities in vitamin E deficiency.
Messenheimer JA, Greenwood RS, Tennison MB, Brickley JJ, Ball CJ.
Ann Neurol. 1984;15(5):499-501.
A patient with cystic fibrosis and cirrhosis developed a progressive neurological syndrome associated with ataxia, proximal weakness, and ophthalmoplegia.
6118719
 MIXED_SAMPLE Infant
Association of spinocerebellar disorders with cystic fibrosis or chronic childhood cholestasis and very low serum vitamin E.
Elias E, Muller DP, Scott J.
Lancet. 1981;2(8259):1319-21.
Neurological syndromes similar to those associated with abetalipoproteinaemia or Friedreich's ataxia developed in four patients with chronic steatorrhoea, two of whom had cystic fibrosis and two chronic cirrhosis of childhood.