Neuroblastoma

Neuroblastoma is a malignant tumor of neural crest cells, the cells that give rise to the sympathetic nervous system, which is observed in children.

Myoclonus

Very brief, involuntary random muscular contractions occurring at rest, in response to sensory stimuli, or accompanying voluntary movements.


Total: 37

                       


(per page)
PMID (PMCID)
27707529
 FEMALE Child
Antineuronal Nuclear Autoantibody Type 1/Anti-Hu-Associated Opsoclonus Myoclonus and Epilepsia Partialis Continua: Case Report and Literature Review.
Sweeney M, Sweney M, Soldan MM, Clardy SL.
Pediatr Neurol. 2016;65:86-89.
There are few reported examples of ANNA-1/anti-Hu antibodies in children with neuroblastoma and opsoclonus-myoclonus, all in children aged less than three years of age.
25596064
 MALE Child
An 8-year old boy with continuous spikes and waves during slow sleep presenting with positive onconeuronal antibodies.
Hu LY, Shi XY, Feng C, Wang JW, Yang G, Lammers SH, Yang XF, Ebrahimi-Fakhari D, Zou LP.
Eur J Paediatr Neurol. 2015;19(2):257-61.
We report the case of an 8-year old boy with a history of neuroblastoma and opsoclonus-myoclonus, who presented with intellectual disability, pharmacotherapy-resistant epilepsy and CSWS/ESES.
25596064
 MALE Child
An 8-year old boy with continuous spikes and waves during slow sleep presenting with positive onconeuronal antibodies.
Hu LY, Shi XY, Feng C, Wang JW, Yang G, Lammers SH, Yang XF, Ebrahimi-Fakhari D, Zou LP.
Eur J Paediatr Neurol. 2015;19(2):257-61.
To determine the etiology of epilepsy with continuous spikes and waves during slow sleep (CSWS)/electrical status epilepticus during sleep (ESES) in an 8-year old boy with a history of neuroblastoma and opsoclonus-myoclonus.
25733762
 MALE Child
Pediatric movement disorders.
Kruer MC.
Pediatr Rev. 2015;36(3):104-15; quiz 116, 129.
On the basis of some research evidence and consensus, identification of acute opsoclonus, ataxia, or myoclonus should prompt consideration of an underlying neuroblastoma.
24995204
 OTHER
Dancing eyes dancing feet syndrome-a report of two cases.
Jasminekalyani P, Saravanan S, V S, M R.
J Clin Diagn Res. 2014;8(5):MD03-5.
Opsoclonus Myoclonus, which manifests itself as post infectious encephalopathy, occasionally along with HIV infection, post Streptococcal infection, West Nile virus encephalitis and Rickettsial infection, most often presents as a paraneoplastic syndrome, which is especially caused by occult neuroblastoma which is commonly seen in childhood and occurs in adults in relation to breast cancer and small cell lung cancer.
23658383
 MIXED_SAMPLE Child
Autoimmune limbic encephalopathy and anti-Hu antibodies in children without cancer.
Honnorat J, Didelot A, Karantoni E, Ville D, Ducray F, Lambert L, Deiva K, Garcia M, Pichit P, Cavillon G, Rogemond V, DeLattre JY, Tardieu M.
Neurology. 2013;80(24):2226-32.
In contrast, of the 8 children, only 2 (25%, Fisher exact test p = 0.0003) had neuroblastoma and opsoclonus-myoclonus.
23827430
 FEMALE
Narcolepsy with cataplexy as presenting symptom of occult neuroblastoma.
Sinsioco C, Silver K, Forrest KM, Gray J, Nechay A, Sheldon S, Chelmicka Schorr E.
Pediatr Neurol. 2013;49(1):64-7.
Neuroblastoma associated with the paraneoplastic syndrome of opsoclonus-myoclonus is well-described.
24163518
(3800304)
 OTHER
Somatostatin receptor positron emission tomography/computed tomography (PET/CT) in the evaluation of opsoclonus-myoclonus ataxia syndrome.
Joshi P, Lele V.
Indian J Nucl Med. 2013;28(2):108-11.
Opsoclonus-myoclonus ataxia (OMA) syndrome is the most common paraneoplastic neurological syndrome of childhood, associated with occult neuroblastoma in 20%-50% of all cases.
21702171
 FEMALE
[A case report on cervical neuroblastoma with ataxia].
Kanemura N, Nakano T, Hirano A, Amatsu H, Koshimo N, Uemura G, Aiba T.
Nihon Jibiinkoka Gakkai Kaiho. 2011;114(5):505-10.
Opsoclonus-myoclonus syndrome is typified by opsoclonus with myoclonus and ataxia, primarily associated with neuroblastoma.
16652344
 FEMALE Infant
Response to rituximab in a child with neuroblastoma and opsoclonus-myoclonus.
Bell J, Moran C, Blatt J.
Pediatr Blood Cancer. 2008;50(2):370-1.
Response to rituximab in a child with neuroblastoma and opsoclonus-myoclonus.
18091597
 FEMALE Infant
Dancing eyes, dancing feet: opsoclonus-myoclonus in an 18-month-old child with neuroblastoma.
Badaki OB, Schapiro ES.
Pediatr Emerg Care. 2007;23(12):885-8.
Dancing eyes, dancing feet: opsoclonus-myoclonus in an 18-month-old child with neuroblastoma.
16939863
 FEMALE
Neuroblastoma found in a 4-year-old after rituximab therapy for opsoclonus-myoclonus.
Chang BH, Koch T, Hopkins K, Malempati S.
Pediatr Neurol. 2006;35(3):213-5.
This report describes the case of an occult neuroblastoma diagnosed in a 4-year-old female 2 years after presentation of opsoclonus-myoclonus.
16939863
 FEMALE
Neuroblastoma found in a 4-year-old after rituximab therapy for opsoclonus-myoclonus.
Chang BH, Koch T, Hopkins K, Malempati S.
Pediatr Neurol. 2006;35(3):213-5.
Neuroblastoma found in a 4-year-old after rituximab therapy for opsoclonus-myoclonus.
16939863
 FEMALE
Neuroblastoma found in a 4-year-old after rituximab therapy for opsoclonus-myoclonus.
Chang BH, Koch T, Hopkins K, Malempati S.
Pediatr Neurol. 2006;35(3):213-5.
Although neuroblastomas can be identified months after presentation of opsoclonus-myoclonus without treatment with rituximab, this report describes one of the longest intervals using up-to-date imaging techniques.
16939863
 FEMALE
Neuroblastoma found in a 4-year-old after rituximab therapy for opsoclonus-myoclonus.
Chang BH, Koch T, Hopkins K, Malempati S.
Pediatr Neurol. 2006;35(3):213-5.
Therefore the case raises two concerns: (1) whether the same immune process that causes opsoclonus-myoclonus may suppress neuroblastomas, and (2) whether immunosuppressive therapy with rituximab may inhibit the immune reaction to occult neuroblastomas in patients with unexplained opsoclonus-myoclonus.
16939863
 FEMALE
Neuroblastoma found in a 4-year-old after rituximab therapy for opsoclonus-myoclonus.
Chang BH, Koch T, Hopkins K, Malempati S.
Pediatr Neurol. 2006;35(3):213-5.
Therefore the case raises two concerns: (1) whether the same immune process that causes opsoclonus-myoclonus may suppress neuroblastomas, and (2) whether immunosuppressive therapy with rituximab may inhibit the immune reaction to occult neuroblastomas in patients with unexplained opsoclonus-myoclonus.
16939863
 FEMALE
Neuroblastoma found in a 4-year-old after rituximab therapy for opsoclonus-myoclonus.
Chang BH, Koch T, Hopkins K, Malempati S.
Pediatr Neurol. 2006;35(3):213-5.
Therefore the case raises two concerns: (1) whether the same immune process that causes opsoclonus-myoclonus may suppress neuroblastomas, and (2) whether immunosuppressive therapy with rituximab may inhibit the immune reaction to occult neuroblastomas in patients with unexplained opsoclonus-myoclonus.
16939863
 FEMALE
Neuroblastoma found in a 4-year-old after rituximab therapy for opsoclonus-myoclonus.
Chang BH, Koch T, Hopkins K, Malempati S.
Pediatr Neurol. 2006;35(3):213-5.
Therefore the case raises two concerns: (1) whether the same immune process that causes opsoclonus-myoclonus may suppress neuroblastomas, and (2) whether immunosuppressive therapy with rituximab may inhibit the immune reaction to occult neuroblastomas in patients with unexplained opsoclonus-myoclonus.
15868878
 MALE
A case of opsoclonus-myoclonus-ataxia with neuroblastoma.
Mukherjee A, Mukherjee A, Chakrabarty S.
J Indian Med Assoc. 2004;102(11):647-8.
A case of opsoclonus-myoclonus-ataxia with neuroblastoma.
15454839
 MALE
Hyperexcitable blink reflex preceding the diagnosis of neuroblastoma.
Ramadan M, Whalen B, De Santes K.
J Pediatr Hematol Oncol. 2004;26(10):665-7.
The diagnosis of neuroblastoma is sometimes preceded by development of a paraneoplastic syndrome, most commonly opsoclonus-myoclonus-ataxia (OMA).