Neuroblastoma

Neuroblastoma is a malignant tumor of neural crest cells, the cells that give rise to the sympathetic nervous system, which is observed in children.

Rosette

A halo or spoke-wheel arrangement of cells surrounding a central core or hub. The central hub may consist of an empty-appearing lumen or a space filled with cytoplasmic processes. The cytoplasm of each of the cells in the rosette is often wedge-shaped with the apex directed toward the central core; the nuclei of the cells participating in the rosette are peripherally positioned and form a ring or halo around the hub.


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PMID (PMCID)
30582192
 FEMALE Middle Aged
Neuroblastoma-like schwannoma with giant rosette: A potential diagnostic pitfall for hyalinizing spindle cell tumor.
Koubaa Mahjoub W, Jouini R, Khanchel F, Ben Brahim E, Llamas-Velasco M, Helel I, Khayat O, Chadli A, Badri T, Mentzel T.
J Cutan Pathol. 2019;46(3):234-237.
Neuroblastoma-like schwannoma with giant rosette: A potential diagnostic pitfall for hyalinizing spindle cell tumor.
30582192
 FEMALE Middle Aged
Neuroblastoma-like schwannoma with giant rosette: A potential diagnostic pitfall for hyalinizing spindle cell tumor.
Koubaa Mahjoub W, Jouini R, Khanchel F, Ben Brahim E, Llamas-Velasco M, Helel I, Khayat O, Chadli A, Badri T, Mentzel T.
J Cutan Pathol. 2019;46(3):234-237.
We propose the term "neuroblastoma-like schwannoma" when there are small rosettes, "HSCT-like schwannoma" for tumors with giant rosettes and "collagen-rich schwannoma" when there are "ill-defined" structures reminiscent of rosettes.
30582192
 FEMALE Middle Aged
Neuroblastoma-like schwannoma with giant rosette: A potential diagnostic pitfall for hyalinizing spindle cell tumor.
Koubaa Mahjoub W, Jouini R, Khanchel F, Ben Brahim E, Llamas-Velasco M, Helel I, Khayat O, Chadli A, Badri T, Mentzel T.
J Cutan Pathol. 2019;46(3):234-237.
We propose the term "neuroblastoma-like schwannoma" when there are small rosettes, "HSCT-like schwannoma" for tumors with giant rosettes and "collagen-rich schwannoma" when there are "ill-defined" structures reminiscent of rosettes.
30582192
 FEMALE Middle Aged
Neuroblastoma-like schwannoma with giant rosette: A potential diagnostic pitfall for hyalinizing spindle cell tumor.
Koubaa Mahjoub W, Jouini R, Khanchel F, Ben Brahim E, Llamas-Velasco M, Helel I, Khayat O, Chadli A, Badri T, Mentzel T.
J Cutan Pathol. 2019;46(3):234-237.
We propose the term "neuroblastoma-like schwannoma" when there are small rosettes, "HSCT-like schwannoma" for tumors with giant rosettes and "collagen-rich schwannoma" when there are "ill-defined" structures reminiscent of rosettes.
29758594
 MALE Infant
PHOX2B is a reliable immunomarker in distinguishing peripheral neuroblastic tumours from CNS embryonal tumours.
Alexandrescu S, Paulson V, Dubuc A, Ligon A, Lidov HG.
Histopathology. 2018;73(3):483-491.
PHOX2B immunostain was performed on 29 paediatric cases, with adequate controls: one retroperitoneal embryonal tumour in a child with retinoblastoma (index 1), one posterior fossa embryonal tumour in a child with a neuroblastoma (index 2), seven medulloblastomas, four atypical teratoid/rhabdoid tumours (ATRT), four retinoblastomas, six pineoblastomas, four embryonal tumours with multilayered rosettes (ETMR) and two CNS embryonal tumours, not elsewhere classified.
26658063
 MALE Infant
Embryonal Tumor With Abundant Neuropil and True Rosettes: A Distinct Immunohistochemical Pattern.
Al-Salam S, Al Alashari M.
Appl Immunohistochem Mol Morphol. 2016;24(6):e41-9.
Embryonal tumors with abundant neuropil and true rosettes (ETANTR) are rare pediatric embryonal neoplasms that combine features of neuroblastoma and ependymoblastoma.
23865520
(3867594)
 FEMALE
The role of CD133+ cells in a recurrent embryonal tumor with abundant neuropil and true rosettes (ETANTR).
Hervey-Jumper SL, Altshuler DB, Wang AC, He X, Maher CO, Robertson PL, Garton HJ, Fan X, Muraszko KM, Camelo-Piragua S.
Brain Pathol. 2014;24(1):45-51.
Embryonal tumor with abundant neuropil and true rosettes (ETANTR) is a recently described embryonal neoplasm of the central nervous system, consisting of a well-circumscribed embryonal tumor of infancy with mixed features of ependymoblastoma (multilayer ependymoblastic rosettes and pseudorosettes) and neuroblastoma (neuroblastic rosettes) in the presence of neuropil-like islands.
23865520
(3867594)
 FEMALE
The role of CD133+ cells in a recurrent embryonal tumor with abundant neuropil and true rosettes (ETANTR).
Hervey-Jumper SL, Altshuler DB, Wang AC, He X, Maher CO, Robertson PL, Garton HJ, Fan X, Muraszko KM, Camelo-Piragua S.
Brain Pathol. 2014;24(1):45-51.
Embryonal tumor with abundant neuropil and true rosettes (ETANTR) is a recently described embryonal neoplasm of the central nervous system, consisting of a well-circumscribed embryonal tumor of infancy with mixed features of ependymoblastoma (multilayer ependymoblastic rosettes and pseudorosettes) and neuroblastoma (neuroblastic rosettes) in the presence of neuropil-like islands.
23865520
(3867594)
 FEMALE
The role of CD133+ cells in a recurrent embryonal tumor with abundant neuropil and true rosettes (ETANTR).
Hervey-Jumper SL, Altshuler DB, Wang AC, He X, Maher CO, Robertson PL, Garton HJ, Fan X, Muraszko KM, Camelo-Piragua S.
Brain Pathol. 2014;24(1):45-51.
Embryonal tumor with abundant neuropil and true rosettes (ETANTR) is a recently described embryonal neoplasm of the central nervous system, consisting of a well-circumscribed embryonal tumor of infancy with mixed features of ependymoblastoma (multilayer ependymoblastic rosettes and pseudorosettes) and neuroblastoma (neuroblastic rosettes) in the presence of neuropil-like islands.
25208992
 MIXED_SAMPLE Infant
[Primitive neuroectodermal tumor of central nervous system with features of ependymoblastoma and neuroblastoma: a clinicopathologic study of 4 cases].
Wang R, Guan W, Wu X, Zhang W, Jiang B, Ma J, Wang L.
Zhonghua Bing Li Xue Za Zhi. 2014;43(6):403-7.
All tumors showed typical combined histological patterns of ependymoblastoma and neuroblastoma, demonstrating zones of true rosettes, occasional pseudovascular rosettes, and undifferentiated neuroepithelial cells in a prominent background of mature neuropils.
25208992
 MIXED_SAMPLE Infant
[Primitive neuroectodermal tumor of central nervous system with features of ependymoblastoma and neuroblastoma: a clinicopathologic study of 4 cases].
Wang R, Guan W, Wu X, Zhang W, Jiang B, Ma J, Wang L.
Zhonghua Bing Li Xue Za Zhi. 2014;43(6):403-7.
All tumors showed typical combined histological patterns of ependymoblastoma and neuroblastoma, demonstrating zones of true rosettes, occasional pseudovascular rosettes, and undifferentiated neuroepithelial cells in a prominent background of mature neuropils.
21194275
 MALE Infant
Embryonal tumors with abundant neuropil and true rosettes: 2 illustrative cases and a review of the literature.
Manjila S, Ray A, Hu Y, Cai DX, Cohen ML, Cohen AR.
Neurosurg Focus. 2011;30(1):E2.
Histologically, this tumor has features of ependymoblastoma and neuroblastoma, demonstrating areas of fine fibrillary neuropil intermingled with ependymoblastic rosettes and zones of undifferentiated neuroepithelial cells.
19922484
 FEMALE Adult
Cutaneous neuroblastoma-like schwannoma: a report of two cases, one with a plexiform pattern, and a review of the literature.
Suchak R, Luzar B, Bacchi CE, Maguire B, Calonje E.
J Cutan Pathol. 2010;37(9):997-1001.
The differential diagnosis includes other lesions with the formation of rosettes including neuroblastoma, low-grade fibromyxoid sarcoma and dendritic cell neurofibroma, as well as primitive neuroectodermal tumors and rare malignant transformation in a schwannoma.
20499240
 FEMALE Infant
Embryonal tumor with abundant neuropil and true rosettes (ETANTR): a new distinctive variety of pediatric PNET: a case-based update.
Ferri Niguez B, Martinez-Lage JF, Almagro MJ, Fuster JL, Serrano C, Torroba MA, Sola J.
Childs Nerv Syst. 2010;26(8):1003-8.
ETANTR is a recently described variety of PNET that combines microscopic features of neuroblastoma and ependymoblastoma, demonstrating areas of fine fibrillary neuropil intermingled with cellular zones and ependymoblastic rosettes.
17641710
 MALE
Neuroblastoma-like schwannoma as a rare cause of proptosis: a case report.
Kukreja M, Gupta R, Julka A, Sharma MC.
Can J Ophthalmol. 2007;42(4):624-5.
Schwannoma with giant rosettes and hyperchromatic small cells was previously designated a neuroblastoma-like schwannoma by Goldblum et al.
16919032
 FEMALE Adult
Rosetoid schwannoma (neuroblastoma-like) in association with an anetoderma.
Velez D, Reina Duran T, Perez-Gala S, Fernandez JF.
J Cutan Pathol. 2006;33(8):573-6.
A cutaneous biopsy showed findings consistent with a neuroblastoma-like schwannoma with the following peculiar features: (i) Being fully composed of rosette-like structures.
15900131
 FEMALE Adult
Schwannoma with neuroblastoma-like rosettes: an unusual morphologic variant.
Lewis ZT, Geisinger KR, Pichardo R, Sangueza OP.
Am J Dermatopathol. 2005;27(3):243-6.
Schwannoma with neuroblastoma-like rosettes: an unusual morphologic variant.
12544097
 OTHER Middle Aged
Neuroblastoma-like schwannoma: a case report and review of the literature.
de Saint Aubain Somerhausen N, Valaeys V, Geerts M, Andre J.
Am J Dermatopathol. 2003;25(1):32-4.
Schwannoma with giant rosettes, previously designated as neuroblastoma-like schwannoma by Goldblum et al., must be differentiated from neuroblastoma, peripheral neuroectodermal tumors, and malignant change in a schwannoma.
12544097
 OTHER Middle Aged
Neuroblastoma-like schwannoma: a case report and review of the literature.
de Saint Aubain Somerhausen N, Valaeys V, Geerts M, Andre J.
Am J Dermatopathol. 2003;25(1):32-4.
Schwannoma with giant rosettes, previously designated as neuroblastoma-like schwannoma by Goldblum et al., must be differentiated from neuroblastoma, peripheral neuroectodermal tumors, and malignant change in a schwannoma.
11843557
 FEMALE Adult
Fine needle aspiration cytology of metastatic olfactory neuroblastoma: a case report.
Chung J, Park ST, Jang J.
Acta Cytol. 2002;46(1):40-5.
ONB, like adrenal neuroblastoma, shows distinctive cytologic features, including a rosette or pseudorosette and fibrillary network.