Neuroblastoma

Neuroblastoma is a malignant tumor of neural crest cells, the cells that give rise to the sympathetic nervous system, which is observed in children.

Sarcoma

A connective tissue neoplasm formed by proliferation of mesodermal cells. Bone and soft tissue sarcomas are the main types of sarcoma. Sarcoma is usually highly malignant.


Total: 64

                       


(per page)
PMID (PMCID)
31258273
 OTHER
Extraskeletal Ewing's Sarcoma Masquerading as Infantile Benign Neck Mass.
Gazula S, Rani VL, Jonathan GT, Kumar NN.
J Indian Assoc Pediatr Surg. 2019;24(3):209-211.
The histologic similarities of Ewing's sarcoma to more common pediatric small-blue-round-cell tumors such as lymphoma and neuroblastoma necessitate immunohistochemistry and molecular genetics for clinching the diagnosis.
30067549
 MALE Adult
Ewing-Like Sarcoma: A Case of a Primary Cutaneous Primitive Neuroectodermal Tumor With Atypical Immunohistochemistry and Lack of Fusion Oncogene Detection.
Labadie JG, Florek AG, VandenBoom T, Yazdan P, Krunic AL.
Am J Dermatopathol. 2018;40(12):890-893.
Differential diagnoses such as rhabdomyosarcoma, desmoplastic small round blue cell tumor, hematolymphoid neoplasm, neuroblastoma, and CIC-DUX round cell sarcoma were ruled out based on immunohistochemistry, genetic studies, and histology.
28529742
(5431636)
 OTHER
Intraductal tubulopapillary neoplasm accompanied by invasive carcinoma of the pancreas: A case report and review of the literature.
Niu L, Xu Z, Liu H, Cao H, Yang G.
Mol Clin Oncol. 2017;6(5):676-682.
The microsatellite instability analysis demonstrated microsatellite stability, without detected gene mutations of epidermal growth factor receptor, Kirsten rat sarcoma viral oncogene homolog, neuroblastoma RAS viral oncogene homolog or B-Raf proto-oncogene.
28500641
 FEMALE Child
T and B cell clonal expansion in Ras-associated lymphoproliferative disease (RALD) as revealed by next-generation sequencing.
Levy-Mendelovich S, Lev A, Rechavi E, Barel O, Golan H, Bielorai B, Neumann Y, Simon AJ, Somech R.
Clin Exp Immunol. 2017;189(3):310-317.
Ras-associated lymphoproliferative disease (RALD) is an autoimmune lymphoproliferative syndrome (ALPS)-like disease caused by mutations in Kirsten rat sarcoma viral oncogene homologue (KRAS) or neuroblastoma RAS viral (V-Ras) oncogene homologue (NRAS).
27068398
(4961521)
 FEMALE Adult
An Activating KIT Mutation Induces Crizotinib Resistance in ROS1-Positive Lung Cancer.
Dziadziuszko R, Le AT, Wrona A, Jassem J, Camidge DR, Varella-Garcia M, Aisner DL, Doebele RC.
J Thorac Oncol. 2016;11(8):1273-1281.
This bypass signaling pathway serves as a ROS1-independent mechanism of resistance, similarly to previously identified epidermal growth factor receptor or Kirsten rat sarcoma viral oncogene homolog/neuroblastoma RAS viral oncogene homolog signaling pathways, and can potentially be targeted by KIT inhibitors.
26825879
(5291549)
 FEMALE Middle Aged
GNA11 Mutation in a Patient With Cutaneous Origin Melanoma: A Case Report.
Patel SP, Kim DW, Lacey CL, Hwu P.
Medicine (Baltimore). 2016;95(4):e2336.
The rapid advances in the molecular biology and genetics have improved the understanding of molecular pathogenesis of v-Raf murine sarcoma viral oncogene homolog B (BRAF), feline sarcoma viral oncogene v-kit (KIT), and neuroblastoma v-Ras oncogene homolog (NRAS) mutant melanomas with the subsequent development of targeted therapeutic agents.
26825879
(5291549)
 FEMALE Middle Aged
GNA11 Mutation in a Patient With Cutaneous Origin Melanoma: A Case Report.
Patel SP, Kim DW, Lacey CL, Hwu P.
Medicine (Baltimore). 2016;95(4):e2336.
The rapid advances in the molecular biology and genetics have improved the understanding of molecular pathogenesis of v-Raf murine sarcoma viral oncogene homolog B (BRAF), feline sarcoma viral oncogene v-kit (KIT), and neuroblastoma v-Ras oncogene homolog (NRAS) mutant melanomas with the subsequent development of targeted therapeutic agents.
25926041
 OTHER
Are all RAS mutations the same? Coexisting KRAS and NRAS mutations in a caecal adenocarcinoma and contiguous tubulovillous adenoma.
Vagaja NN, Parry J, McCallum D, Thomas MA, Bentel JM.
J Clin Pathol. 2015;68(8):657-60.
Mutations of the human Kirsten rat sarcoma viral oncogene homologue (KRAS) and the highly homologous human neuroblastoma RAS viral oncogene homologue (NRAS) are associated with resistance to antiepidermal growth factor receptor therapies in patients with colorectal cancer.
24943771
 MALE Young Adult
Primary primitive neuroectodermal tumor of kidney: a rare case report with diagnostic challenge.
Kakkar S, Gupta D, Kaur G, Rana V.
Indian J Pathol Microbiol. 2014;57(2):298-300.
Primary primitive neuroectodermal tumors (PNETs) of the kidney are quite rare and can be mistaken for a wide variety of other small round blue cell tumors which includes rhabdomyosarcoma, Wilm's tumor, carcinoid, neuroblastoma, clear cell sarcoma of the kidney, lymphoma etc.
23079204
 MIXED_SAMPLE Middle Aged
Papillary thyroid microcarcinoma with fatal outcome: evidence of tumor progression in lymph node metastases: report of 3 cases, with morphological and molecular analysis.
Piana S, Ragazzi M, Tallini G, de Biase D, Ciarrocchi A, Frasoldati A, Rosai J.
Hum Pathol. 2013;44(4):556-65.
In addition to morphology, immunohistochemical (cyclin D1 and p53) and molecular analyses (BRAF [v-raf Murine sarcoma viral oncogene homolog B1], KRAS [V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog], HRAS [v-Ha-ras Harvey rat sarcoma viral oncogene homolog], NRAS [neuroblastoma RAS viral oncogene homolog], and PIK3CA [phosphoinositide-3-kinase, catalytic, alpha polypeptide]) were performed.
23079204
 MIXED_SAMPLE Middle Aged
Papillary thyroid microcarcinoma with fatal outcome: evidence of tumor progression in lymph node metastases: report of 3 cases, with morphological and molecular analysis.
Piana S, Ragazzi M, Tallini G, de Biase D, Ciarrocchi A, Frasoldati A, Rosai J.
Hum Pathol. 2013;44(4):556-65.
In addition to morphology, immunohistochemical (cyclin D1 and p53) and molecular analyses (BRAF [v-raf Murine sarcoma viral oncogene homolog B1], KRAS [V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog], HRAS [v-Ha-ras Harvey rat sarcoma viral oncogene homolog], NRAS [neuroblastoma RAS viral oncogene homolog], and PIK3CA [phosphoinositide-3-kinase, catalytic, alpha polypeptide]) were performed.
23079204
 MIXED_SAMPLE Middle Aged
Papillary thyroid microcarcinoma with fatal outcome: evidence of tumor progression in lymph node metastases: report of 3 cases, with morphological and molecular analysis.
Piana S, Ragazzi M, Tallini G, de Biase D, Ciarrocchi A, Frasoldati A, Rosai J.
Hum Pathol. 2013;44(4):556-65.
In addition to morphology, immunohistochemical (cyclin D1 and p53) and molecular analyses (BRAF [v-raf Murine sarcoma viral oncogene homolog B1], KRAS [V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog], HRAS [v-Ha-ras Harvey rat sarcoma viral oncogene homolog], NRAS [neuroblastoma RAS viral oncogene homolog], and PIK3CA [phosphoinositide-3-kinase, catalytic, alpha polypeptide]) were performed.
23084213
 MALE
Clear cell sarcoma of the gastrointestinal tract after very low-dose therapeutic radiation therapy: a case report.
Yang JC, Chou AJ, Oeffinger KC, La Quaglia MP, Wolden SL.
J Pediatr Surg. 2012;47(10):1943-5.
We report a case of a patient who subsequently developed clear cell sarcoma of the gastrointestinal tract nearly 15 years after treatment with very low-dose therapeutic RT (4.5 Gy) for Stage 4S neuroblastoma.
23378886
 MALE Infant
Unusual Concentration of Tc-99m methylendiphosphonate in Rhabdomyosarcoma.
Franco A, Henderson PR, McDonough CH.
J Radiol Case Rep. 2012;6(9):29-34.
Extraosseous accumulation of bone-seeking agents is rare, but has been previously reported in pediatric sarcomas and neuroblastomas.
22212917
 MIXED_SAMPLE Child
Brain metastases in paediatric patients: characteristics of a patient series and review of the literature.
Stefanowicz J, Iycka-wieszewska E, Szurowska E, Bien E, Szarszewski A, Liberek A, Stempniewicz M, Kloc W, Adamkiewicz-Droynska E.
Folia Neuropathol. 2011;49(4):271-81.
The analysed patients were diagnosed with soft tissue sarcomas (three), germ cell tumours (three), or osteosarcoma, neuroblastoma, clear cell sarcoma of the kidney, or pleuropulmonary blastoma (one each).
19922484
 FEMALE Adult
Cutaneous neuroblastoma-like schwannoma: a report of two cases, one with a plexiform pattern, and a review of the literature.
Suchak R, Luzar B, Bacchi CE, Maguire B, Calonje E.
J Cutan Pathol. 2010;37(9):997-1001.
The differential diagnosis includes other lesions with the formation of rosettes including neuroblastoma, low-grade fibromyxoid sarcoma and dendritic cell neurofibroma, as well as primitive neuroectodermal tumors and rare malignant transformation in a schwannoma.
19530098
 FEMALE
Intranuclear cytoplasmic inclusions--an extremely unusual finding in embryonal rhabdomyosarcoma: Report of a case diagnosed by fine-needle aspiration biopsy.
Kumar S, Siddaraju N, Singh N, Basu D, Srinivasan R.
Diagn Cytopathol. 2009;37(10):740-3.
Despite the diagnostic dilemma caused by this unusual finding, a differential diagnosis of peripheral neurectodermal tumor (PNET) /Ewing's sarcoma, neuroblastoma, and ERMS was considered.
17362818
 FEMALE Middle Aged
Small cell carcinoma of the submandibular gland: a rare small round blue cell tumor.
Walters DM, Little SC, Hessler RB, Gourin CG.
Am J Otolaryngol. 2007;28(2):118-21.
These include lymphoma, Ewing's sarcoma, melanoma, esthesioneuroblastoma, and neuroblastoma.
15349982
 MIXED_SAMPLE Adult
Fine-needle aspiration of adult small-round-cell tumors studied with flow cytometry.
Leon ME, Hou JS, Galindo LM, Garcia FU.
Diagn Cytopathol. 2004;31(3):147-54.
We describe three patients with Ewing's sarcoma/primitive neuroectodermal tumor (ES/PNET) and one patient with neuroblastoma in which flow cytometry immunophenotyping (FCI) on the fine-needle aspirate (FNA) and bone marrow aspirate (BMA) demonstrated an abnormal population of cells that were CD45(-) and CD16/CD56(+).
12497294
 MALE Middle Aged
[Paraneoplastic cerebellar degeneration as initial presentation of a pancreatic small-cell carcinoma].
Salmeron-Ato P, Medrano V, Morales-Ortiz A, Martinez-Garcia FA, Villaverde-Gonzalez R, Bas A, Fernandez-Barreiro A, Molto-Jorda JM.
Rev Neurol. 2002;35(12):1112-5.
The association of anti Hu immunity and paraneoplastic encephalomyelitis has been observed in patients with neuroblastoma, seminomas, colorectal, breast and prostate carcinomas and some types of sarcoma.