Neurofibromatosis type 1

Neurofibromatosis type 1 (NF1) is a clinically heterogeneous, neurocutaneous genetic disorder characterized by café-au-lait spots, iris Lisch nodules, axillary and inguinal freckling, and multiple neurofibromas.

Leukemia

A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes.


Total: 7

                       


(per page)
PMID (PMCID)
17178664
 MALE Child
Parvovirus B-19 induced acute pure red cell aplasia in patients with chronic lymphocytic leukemia and neurofibromatosis type-1.
Sharma P, Singh T, Mishra D, Gaiha M.
Hematology. 2006;11(4):257-9.
Parvovirus B-19 induced acute pure red cell aplasia in patients with chronic lymphocytic leukemia and neurofibromatosis type-1.
17178664
 MALE Child
Parvovirus B-19 induced acute pure red cell aplasia in patients with chronic lymphocytic leukemia and neurofibromatosis type-1.
Sharma P, Singh T, Mishra D, Gaiha M.
Hematology. 2006;11(4):257-9.
We present two cases, an adult patient with chronic lymphocytic leukemia (CLL) and a child with neurofibromatosis type-1 (NF-1), where the abrupt appearance of severe anemia raised ominous clinical suspicions.
16341812
 MIXED_SAMPLE Child
Syndrome of early onset colon cancers, hematologic malignancies & features of neurofibromatosis in HNPCC families with homozygous mismatch repair gene mutations.
Bandipalliam P.
Fam Cancer. 2005;4(4):323-33.
Furthermore, there has also been some evidence that the neurofibromatosis type-1 gene is a mutational target of the mismatch repair deficiency that is seen in families with HNPCC, and that mlh1 deficiency can accelerate the development of leukemia in neurofibromatosis (Nf1) heterozygous mice.
8177146
 MALE
Juvenile xanthogranuloma and acute leukemia: a case report.
Rotte JJ, de Vaan GA, Koopman RJ.
Med Pediatr Oncol. 1994;23(1):57-9.
It is seen in combination with juvenile chronic myelo-monocytic leukemia (JCML) and/or neurofibromatosis type 1 (NF1).
8174003
 MALE Middle Aged
Neurofibromatosis, acute myelomonocytic leukemia, and disseminated tuberculosis: an adult case report.
Chiou SC, Hwang WL, Chen MC, Gau JP.
Zhonghua Yi Xue Za Zhi (Taipei). 1994;53(1):62-5.
This case further illustrated an association between acute nonlymphocytic leukemia (ANLL) and neurofibromatosis type 1 (NF-1) in adulthood.
1452676
 MALE Child
Fatal disseminated infection caused by Myceliophthora thermophila, a new agent of mycosis: case history and laboratory characteristics.
Bourbeau P, McGough DA, Fraser H, Shah N, Rinaldi MG.
J Clin Microbiol. 1992;30(11):3019-23.
A 7-year-old male with neurofibromatosis (type 1) was diagnosed in 1987 with acute myeloblastic leukemia associated with the chromosomal abnormality monosomy 7.
821339
 FEMALE
Von Recklinghausen neurofibromatosis and acute leukemia.
Reich SD, Wiernik PH.
Am J Dis Child. 1976;130(8):888-9.
Although the number of cases in the literature suggests that in children with von Recklinghausen disease there is a greater risk of leukemia developing, prospective studies are needed to prove this point.