Total: 1 |
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PMID (PMCID) | ||
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12531231 |
MALE | Infant |
B lineage acute lymphoblastic leukemia transformation in a child with juvenile myelomonocytic leukemia, type 1 neurofibromatosis and monosomy of chromosome 7. Possible implications in the leukemogenesis. | ||
Scrideli CA, Baruffi MR, Rogatto SR, Valera ET, Defavery R, Tone LG. Leuk Res. 2003;27(4):371-4. |
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Our results support the theory that JMML may derive from pluripotential cells and that the occurrence of monosomy of chromosome 7 within a clone of cells having an aberrant neurofibromatosis type 1 (NF1) gene may be the cause of JMML and acute leukemia. |