Polyneuropathy associated with IgM monoclonal gammapathy with anti-MAG

Polyneuropathy associated with IgM monoclonal gammapathy (MG) with anti-MAG (myelin-associated-glycoprotein) activity is a demyelinating polyneuropathy characterized clinically by sensory ataxia, tremor, paresthesia, and impaired gait.

Polyneuropathy

A generalized disorder of peripheral nerves.


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PMID (PMCID)
25572169
 MIXED_SAMPLE Middle Aged
IgM MGUS associated with anti-MAG neuropathy: a single institution experience.
Talamo G, Mir MA, Pandey MK, Sivik JK, Raheja D.
Ann Hematol. 2015;94(6):1011-6.
Anti-MAG neuropathy is a very rare form of acquired polyneuropathy associated with IgM monoclonal gammopathy of undetermined significance (MGUS).
22019868
 MALE Middle Aged
[Rapid improvement by rituximab treatment in a case of demyelinating polyneuropathy with anti-myelin-associated glycoprotein antibody].
Motoyama R, Yamakawa K, Suzuki S, Kusunoki S, Tanaka M.
Rinsho Shinkeigaku. 2011;51(10):761-4.
Polyneuropathy associated with antibodies directed against myelin-associated glycoprotein (MAG) is a chronic symmetric sensorimotor demyelinating neuropathy caused by monoclonal IgM against MAG (anti-MAG neuropathy).
7938961
 FEMALE Middle Aged
[Multiple complications of monoclonal IgM].
Soubrier M, Dubost JJ, Jouanel P, Tridon A, Flori B, Leguille C, Ristori JM, Bussiere JL.
Rev Med Interne. 1994;15(7):484-6.
The polyneuropathy was consistent with an IgM anti MAG neuropathy rather than a cryoglobulinemic neuropathy.