Malaria

A life-threatening parasitic disease caused by <i>Plasmodium</i> (<i>P. </i>) parasites that are transmitted by <i>Anophles</i> mosquito bites to humans and is typically clinically characterized by attacks of fever, headache, chills and vomiting.

Agranulocytosis

Marked decrease in the number of granulocytes.


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PMID (PMCID)
8942159
 FEMALE Adult
Dapsone agranulocytosis in a leprosy patient.
Hiran S, Pande TK, Pani S, Vishwanathan KA.
Lepr Rev. 1994;65(3):279-81.
There are various reports of agranulocytosis in patients treated with dapsone for malaria prophylaxis and other dermatological diseases.
6473241
 MALE Middle Aged
Agranulocytosis during malaria prophylaxis with Maloprim (pyrimethamine and dapsone).
Booth F, Barker LC, Barton CJ, Naik RB.
Postgrad Med J. 1984;60(706):566-7.
Agranulocytosis during malaria prophylaxis with Maloprim (pyrimethamine and dapsone).
6665534
 FEMALE
[Amodiaquine-induced agranulocytosis in malaria prevention: demonstration of an amodiaquine-induced cytotoxic antibody against granulocytes].
Schulthess HK, von Felten A, Gmur J, Neftel K.
Schweiz Med Wochenschr. 1983;113(50):1912-3.
[Amodiaquine-induced agranulocytosis in malaria prevention: demonstration of an amodiaquine-induced cytotoxic antibody against granulocytes].
909500
 FEMALE Adult
Agranulocytosis due to dapsone.
Firkin FC, Mariani AF.
Med J Aust. 1977;2(8):247-51.
Agranulocytosis has previously been reported after administration of dapsone for other dermatological disorders, leprosy, and prophylaxis against falciparum malaria.