Polycythemia vera

Polycythemia vera (PV) is an acquired myeloproliferative disorder characterized by an elevated absolute red blood cell mass caused by uncontrolled red blood cell production, frequently associated with uncontrolled white blood cell and platelet production.

Splenomegaly

Abnormal increased size of the spleen.


Total: 12

                       


(per page)
PMID (PMCID)
28781268
 FEMALE Middle Aged
Successful management of splenomegaly with ruxolitinib prior to allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia transformed from post-polycythemia vera myelofibrosis.
Fujishima M, Fujishima N, Kitadate A, Guo Y, Watanabe A, Ubukawa K, Nara M, Yoshioka T, Kameoka Y, Takahashi N.
Rinsho Ketsueki. 2017;58(7):743-748.
Successful management of splenomegaly with ruxolitinib prior to allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia transformed from post-polycythemia vera myelofibrosis.
28794380
(5635310)
 MIXED_SAMPLE Middle Aged
Tumor Lysis Syndrome after the Administration of Ruxolitinib in a Patient with Post-polycythemia Vera Myelofibrosis.
Koshiishi M, Sueki Y, Kawashima I, Nakajima K, Mitsumori T, Kirito K.
Intern Med. 2017;56(17):2335-2338.
We herein present the case of a post-polycythemia vera (PV) myelofibrosis patient with massive splenomegaly who developed laboratory TLS after treatment with ruxolitinib, a potent JAK1/JAK2 inhibitor.
24382738
 MALE Middle Aged
Complex karyotype in a polycythemia vera patient with a novel SETD1B/GTF2H3 fusion gene.
Tiziana Storlazzi C, Pieri L, Paoli C, Daniele G, Lasho T, Tefferi A, Vannucchi AM.
Am J Hematol. 2014;89(4):438-42.
The patient had been diagnosed with polycythemia vera (PV) in 1999, at the age of 61, according to the criteria of the Polycythemia Vera Study Group (PVSG) on the basis of the increased red cell mass by isotope determination, normal oxygen saturation, low plasma erythropoietin level, presence of endogenous erythroid colonies (EEC), and splenomegaly.
24382738
 MALE Middle Aged
Complex karyotype in a polycythemia vera patient with a novel SETD1B/GTF2H3 fusion gene.
Tiziana Storlazzi C, Pieri L, Paoli C, Daniele G, Lasho T, Tefferi A, Vannucchi AM.
Am J Hematol. 2014;89(4):438-42.
The patient had been diagnosed with polycythemia vera (PV) in 1999, at the age of 61, according to the criteria of the Polycythemia Vera Study Group (PVSG) on the basis of the increased red cell mass by isotope determination, normal oxygen saturation, low plasma erythropoietin level, presence of endogenous erythroid colonies (EEC), and splenomegaly.
22157736
 MIXED_SAMPLE Adult
How to manage polycythemia vera.
Passamonti F.
Leukemia. 2012;26(5):870-4.
In the case of a patient with erythrocytosis and other signs of myeloproliferation, such as leukocytosis, thrombocytosis or splenomegaly, the diagnosis of polycythemia vera (PV) is likely, and I test serum erythropoietin and JAK2 mutations first.
21393891
 MIXED_SAMPLE Middle Aged
JAK2-positive Philadelphia-negative myeloproliferative neoplasms.
Sharma A, Buxi G, Marwah S, Yadav R.
Indian J Pathol Microbiol. 2011;54(1):117-20.
Here are two cases which incidentally presented with splenomegaly and moderate leukocytosis, and were diagnosed as MPN-primary myelofibrosis (PMF) in prefibrotic phase and polycythemia vera (PV), respectively, using revised World Health Organization (WHO) 2008 criteria.
12683904
 MALE
Hairy cell leukemia variant developing in a background of polycythemia vera.
Kelly NP, Alkan S, Nand S.
Arch Pathol Lab Med. 2003;127(4):e209-11.
We report a case of hairy cell leukemia variant developing in a background of polycythemia vera in a 77-year-old man who presented with lymphocytosis and splenomegaly.
12051593
 FEMALE Child
Polycythemia vera in a 12-year-old girl: a case report.
Turker M, Ozer EA, Oniz H, Atabay B, Yaprak I.
Pediatr Hematol Oncol. 2002;19(4):263-6.
A case of a 12-year-old girl presenting with headache and splenomegaly and fulfilling the diagnostic criteria of polycythemia vera is reported.
9409109
 MALE Middle Aged
Retinopathy secondary to anemia from myeloid metaplasia in polycythemia vera.
Blood AM, Lowenthal EA, Nowakowski RW.
J Am Optom Assoc. 1997;68(11):734-8.
Polycythemia vera is a chronic clonal disorder associated with excessive proliferation of erythrocytes, leukocytes, and thrombocytes, as well as an accompanying splenomegaly.
8997130
 FEMALE Middle Aged
[Polycythemia vera progressing to acute lymphoblastic leukemia after 13 years].
Arai Y, Masuda M, Okamura T, Wada M, Motoji T, Mizoguchi H.
Rinsho Ketsueki. 1996;37(12):1405-9.
Based on findings of pancytosis, high NAP score, high serum vitamin B12, increase in total red cell volume and splenomegaly, she was diagnosed as having polycythemia vera (PV).
3479003
 FEMALE
Philadelphia chromosome-positive thrombocythemia and megakaryoblast leukemia.
Michiels JJ, Prins ME, Hagermeijer A, Brederoo P, van der Meulen J, van Vliet HH, Abels J.
Am J Clin Pathol. 1987;88(5):645-52.
The presentation with excessive small and abnormal megakaryocytes in the initial and subsequent bone marrow and the rapid progressive myelofibrosis and splenomegaly differentiate the Ph1 chromosome-positive thrombocythemia from the chronic myeloproliferation of thrombocythemia in its primary form or associated with polycythemia vera.
353725
 MIXED_SAMPLE Adult
[Familial myeloproliferative syndromes. Study of 6 families and review of literature].
Kaufman S, Briere J, Bernard J.
Nouv Rev Fr Hematol. 1978;20(1):1-15.
4 : DM, polycythemia vera, the mother and a sister with splenomegaly.