Polycythemia vera

Polycythemia vera (PV) is an acquired myeloproliferative disorder characterized by an elevated absolute red blood cell mass caused by uncontrolled red blood cell production, frequently associated with uncontrolled white blood cell and platelet production.

Leukemia

A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes.


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(per page)
PMID (PMCID)
29685167
(5914053)
 MALE
Neutropenia caused by hairy cell leukemia in a patient with myelofibrosis secondary to polycythemia vera: a case report.
Habberstad AH, Tran HTT, Randen U, Spetalen S, Dybedal I, Tjonnfjord GE, Dahm AEA.
J Med Case Rep. 2018;12(1):105.
In this case report, we describe a patient with polycythemia vera and unexplained neutropenia who later turned out to also have hairy cell leukemia.
29685167
(5914053)
 MALE
Neutropenia caused by hairy cell leukemia in a patient with myelofibrosis secondary to polycythemia vera: a case report.
Habberstad AH, Tran HTT, Randen U, Spetalen S, Dybedal I, Tjonnfjord GE, Dahm AEA.
J Med Case Rep. 2018;12(1):105.
Neutropenia caused by hairy cell leukemia in a patient with myelofibrosis secondary to polycythemia vera: a case report.
29685167
(5914053)
 MALE
Neutropenia caused by hairy cell leukemia in a patient with myelofibrosis secondary to polycythemia vera: a case report.
Habberstad AH, Tran HTT, Randen U, Spetalen S, Dybedal I, Tjonnfjord GE, Dahm AEA.
J Med Case Rep. 2018;12(1):105.
Hairy cell leukemia may mimic development to myelofibrosis in patients with polycythemia vera.
30562793
 MALE Middle Aged
[A case of gout secondary to primary myelofibrosis].
Ji LL, Hao YJ, Zhang ZL.
Beijing Da Xue Xue Bao Yi Xue Ban. 2018;50(6):1117-1119.
However,it is relatively rare to see gout associated with myeloproliferative diseases, including polycythemia vera, primary thrombocythemia, primary myelofibrosis and chronic myelocytic leukemia.
27710990
(6074321)
 MALE Middle Aged
Coexistence of chronic lymphocytic leukemia and polycythemia vera: a case report and review of the literature.
Korkmaz S, Kulakoglu S, Gorkem H, Aygun B, Cetinkaya A.
Ann Saudi Med. 2016;36(5):364-366.
The association of chronic lymphocytic leukemia with polycythemia vera is a rare event with only a few cases of coexistence ever reported.
27710990
(6074321)
 MALE Middle Aged
Coexistence of chronic lymphocytic leukemia and polycythemia vera: a case report and review of the literature.
Korkmaz S, Kulakoglu S, Gorkem H, Aygun B, Cetinkaya A.
Ann Saudi Med. 2016;36(5):364-366.
Coexistence of chronic lymphocytic leukemia and polycythemia vera: a case report and review of the literature.
27389715
 MIXED_SAMPLE Adult
Cooperation of germ line JAK2 mutations E846D and R1063H in hereditary erythrocytosis with megakaryocytic atypia.
Kapralova K, Horvathova M, Pecquet C, Fialova Kucerova J, Pospisilova D, Leroy E, Kralova B, Milosevic Feenstra JD, Schischlik F, Kralovics R, Constantinescu SN, Divoky V.
Blood. 2016;128(10):1418-23.
Both mutations were detected in the germ line of rare polycythemia vera, as well as certain leukemia patients, suggesting that they might predispose to hematological malignancy.
26187587
(4506443)
 FEMALE
BCR-ABL1- positive chronic myeloid leukemia with erythrocytosis presenting as polycythemia vera: a case report.
Cornea MI, Levrat E, Pugin P, Betticher DC.
J Med Case Rep. 2015;9:30.
The World Health Organization classification of chronic myeloproliferative disease encompasses eight entities of bone marrow neoplasms, among them Breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1-positive chronic myeloid leukemia and polycythemia vera.
26187587
(4506443)
 FEMALE
BCR-ABL1- positive chronic myeloid leukemia with erythrocytosis presenting as polycythemia vera: a case report.
Cornea MI, Levrat E, Pugin P, Betticher DC.
J Med Case Rep. 2015;9:30.
To date, this case is the first description of a Breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1-positive chronic myeloid leukemia, presenting with erythrocytosis as the initial manifestation, and mimicking a Janus kinase 2 V617F-negative polycythemia vera.
26187587
(4506443)
 FEMALE
BCR-ABL1- positive chronic myeloid leukemia with erythrocytosis presenting as polycythemia vera: a case report.
Cornea MI, Levrat E, Pugin P, Betticher DC.
J Med Case Rep. 2015;9:30.
Polycythemia vera requires, in the majority of cases (95%), the negativity of Breakpoint cluster region-Abelson murine leukemia viral oncogene homolog 1 rearrangement and the presence of the Janus kinase 2 mutation.
23330877
 FEMALE Young Adult
Ectopic extramedullary hematopoiesis: evaluation and treatment of a rare and benign paraspinal/epidural tumor.
Mattei TA, Higgins M, Joseph F, Mendel E.
J Neurosurg Spine. 2013;18(3):236-42.
Although previous reports have documented EMH presenting as paraspinal masses, such lesions have almost always been associated with a predisposing hematological disorder such as hemolytic anemia, myelofibrosis or myelodysplastic syndromes, thalassemia, polycythemia vera, leukemia, or lymphoma.
23759877
 MALE
Eosinophilic fasciitis as a manifestation of a cutaneous T-cell lymphoma not otherwise specified.
Castellanos-Gonzalez M, Velasco Rodriguez D, Blanco Echevarria A, Postigo C, Ortiz Romero P, Diaz RA, Rodriguez-Peralto JL.
Am J Dermatopathol. 2013;35(6):666-70.
Although several reports indicate the relationship between EF and hematological disorders such as aplastic anemia, polycythemia vera, or myelomonocytic leukemia, the association with lymphomas is extremely rare.
21393910
 MALE Infant
Childhood acute erythroleukemia diagnosis by flow cytometry.
Sharma A, Buxi G, Walia R, Yadav RB, Sharma S.
Indian J Pathol Microbiol. 2011;54(1):173-5.
Flow cytometry can be comprehensive enough to completely subtype cases of leukemias/myelodysplastic syndromes, polycythemia rubra vera, non-neoplastic conditions like reactive erythroid hyperplasia following immunosuppressive therapy or viral infections or nutritional deficiencies, unlyzed RBCs or thrombocytosis which may mimic acute erythroid leukemia on flow cytometry.
19858050
 MALE Adult
Emergence of chronic myelogenous leukemia from a background of myeloproliferative disorder: JAK2V617F as a potential risk factor for BCR-ABL translocation.
Pingali SR, Mathiason MA, Lovrich SD, Go RS.
Clin Lymphoma Myeloma. 2009;9(5):E25-9.
The polycythemia vera clinical and molecular findings were suppressed at the time of CML diagnosis, only to re-emerge after the leukemia was successfully treated with imatinib.
18432364
 MALE Middle Aged
[Concurrent lymphoproliferative and myeloproliferative disorders in three patients].
Hernandez Sanchez MC, Garcia Quiroga H, Ulibarrena Redondo C, Mendez Sanchez JA.
An Med Interna. 2008;25(2):78-80.
We present two patients with a diagnosis of chronic lymphoproliferative syndrome, chronic lymphocytic leukemia B (CLL B) and lymphoplasmacytic non-Hodgkin's lymphoma (NHL), who developed chronic myeloproliferative syndrome: polycythemia vera (PV) and Philadelphia-positive chronic myeloid leukemia (CML) respectively, and a third patient with chronic myeloproliferative syndrome, polycythemia vera (PV), who developed an undefined immunophenotype cyclin D1-positive chronic lymphoproliferative syndrome.
18432364
 MALE Middle Aged
[Concurrent lymphoproliferative and myeloproliferative disorders in three patients].
Hernandez Sanchez MC, Garcia Quiroga H, Ulibarrena Redondo C, Mendez Sanchez JA.
An Med Interna. 2008;25(2):78-80.
We present two patients with a diagnosis of chronic lymphoproliferative syndrome, chronic lymphocytic leukemia B (CLL B) and lymphoplasmacytic non-Hodgkin's lymphoma (NHL), who developed chronic myeloproliferative syndrome: polycythemia vera (PV) and Philadelphia-positive chronic myeloid leukemia (CML) respectively, and a third patient with chronic myeloproliferative syndrome, polycythemia vera (PV), who developed an undefined immunophenotype cyclin D1-positive chronic lymphoproliferative syndrome.
17963181
 MIXED_SAMPLE Child
Ultrastructural characteristics of bone marrow in patients with hematological disease: a study of 13 cases.
Ru YX, Zhao SX, Liu EB, Yang QY, Liu JH, Pang TX, Chen HS.
Ultrastruct Pathol. 2007;31(5):327-32.
In addition, excessive blood cell death in leukemia, apoptosis, and macrophage phagocytosis in myelodysplastic syndrome and polycythemia vera, as well as degranulation of eosinophils and megakaryocytes in chronic idiopathic myelofibrosis were predominant, respectively.
16796632
 MIXED_SAMPLE Child
Sweet's syndrome from an Indian perspective: a report of four cases and review of the literature.
Mahajan VK, Sharma NL, Sharma RC.
Int J Dermatol. 2006;45(6):702-8.
Associated hematoligic disorders recorded were myelodysplasia in three, polycythemia vera in one and leukemia in three patients respectively.
12606138
 FEMALE Middle Aged
Translocation (X;20)(q13.1;q13.3) as a primary chromosomal finding in two patients with myelocytic disorders.
Gray BA, Cornfield D, Bent-Williams A, Zori RT.
Cancer Genet Cytogenet. 2003;141(2):169-74.
Herein, we report the detection, by conventional cytogenetic methods, of a cytogenetically identical t(X;20) in two different patients with hematologic disorders (probable myelodysplasia and polycythemia vera/acute myelocytic leukemia).
12243551
 FEMALE
Simultaneous occurrence of polycythemia vera and Waldenstrom macroglobulinemia: a case report and review of the literature.
Saba NF, Warth JA, Ross DG.
Haematologia (Budap). 2002;32(1):17-23.
Lymphoproliferative disorders reported to occur simultaneously with polycythemia vera include chronic lymphocytic leukemia (CLL), non-Hodgkin's lymphoma (NHL), and acute lymphoblastic leukemia (ALL).