Polycythemia vera

Polycythemia vera (PV) is an acquired myeloproliferative disorder characterized by an elevated absolute red blood cell mass caused by uncontrolled red blood cell production, frequently associated with uncontrolled white blood cell and platelet production.

Acute leukemia

A clonal (malignant) hematopoietic disorder with an acute onset, affecting the bone marrow and the peripheral blood. The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts).


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PMID (PMCID)
24697128
 FEMALE Middle Aged
Polycythemia vera transforming to myelofibrosis and then biphenotype acute leukemia.
Dong XF, Yue LZ, Fu R, Shao ZH.
Clin Lab. 2014;60(3):495-9.
A case with 17-year detailed illness history including evolution of polycythemia vera (PV) to myelofibrosis (MF) and then biphenotype acute leukemia (BAL) was reported.
12454709
 MALE Middle Aged
Megakaryoblastic transformation of polycythemia vera with hypercalcemia.
Kurosawa M, Iwasaki H.
Ann Hematol. 2002;81(11):668-71.
Polycythemia vera (PV) is known to occasionally transform into acute leukemia.
11845984
 FEMALE Middle Aged
Leukemic transformation of polycythemia vera after treatment with hydroxyurea with abnormalities of chromosome 17.
Tothova E, Fricova M, Stecova N, Hlebaskova M, Kafkova A, Raffac S, Guman T, Svorcova E, Nebesnakova E.
Neoplasma. 2001;48(5):389-92.
But there exist reports, which showed the development of polycythemia vera into acute leukemia not only in patients treated with alkylating agents and radiophosphorus but also with single hydroxyurea.
9364871
 FEMALE
[CD7+, CD34+, electronmicroscopically peroxidase-negative acute leukemia transformed from polycythemia vera after 12 years follow-up].
Kuno Y, Takeo T, Kawashima K.
Rinsho Ketsueki. 1997;38(9):782-7.
[CD7+, CD34+, electronmicroscopically peroxidase-negative acute leukemia transformed from polycythemia vera after 12 years follow-up].
9364871
 FEMALE
[CD7+, CD34+, electronmicroscopically peroxidase-negative acute leukemia transformed from polycythemia vera after 12 years follow-up].
Kuno Y, Takeo T, Kawashima K.
Rinsho Ketsueki. 1997;38(9):782-7.
We reported a 72-year-old female patient who developed acute leukemia following a long course of polycythemia vera (PV).
8035619
 MALE Adult
A case of polycythemia vera occurring in a patient with acute non-lymphoblastic leukemia (ANLL) in long-term first complete remission.
Chabannon C, Bost M, Hollard D.
Leukemia. 1994;8(7):1243-4.
Polycythemia vera (PV) is a chronic myeloproliferative syndrome which in a minority of patients evolves into acute leukemia.
3369437
 MIXED_SAMPLE Adult
Acute leukemia following treatment of polycythemia vera and essential thrombocythemia with uracil mustard.
Toh BT, Gregory SA, Knospe WH.
Am J Hematol. 1988;28(1):58-60.
Transformation to acute leukemia (AL) is known to occur in polycythemia vera (PV) and essential thrombocythemia (ET).
3369437
 MIXED_SAMPLE Adult
Acute leukemia following treatment of polycythemia vera and essential thrombocythemia with uracil mustard.
Toh BT, Gregory SA, Knospe WH.
Am J Hematol. 1988;28(1):58-60.
Acute leukemia following treatment of polycythemia vera and essential thrombocythemia with uracil mustard.
6308798
 MIXED_SAMPLE Adult
[Hematologic and cytogenetic study of 7 cases of preleukemic state or acute leukemia following the treatment of a first malignancy].
Smadja N, Krulik M, Audebert AA, Brissaud P, Debray J.
Sem Hop. 1983;59(23):1729-35.
The authors present 7 cases of preleukemic state and/or acute leukemia following the treatment of a first malignancy (3 malignant lymphomas, 3 epithelial cancers and one polycythemia vera).
6953605
 MALE
Acute leukemia as a transformation after polycythemia vera.
Eisemann G, Kahn M.
South Med J. 1982;75(6):772-3.
The development of acute leukemia as a natural progression of polycythemia vera is very rare.
6953605
 MALE
Acute leukemia as a transformation after polycythemia vera.
Eisemann G, Kahn M.
South Med J. 1982;75(6):772-3.
Acute leukemia as a transformation after polycythemia vera.
6953605
 MALE
Acute leukemia as a transformation after polycythemia vera.
Eisemann G, Kahn M.
South Med J. 1982;75(6):772-3.
We have described a patient who had acute leukemia within one month after the diagnosis of polycythemia vera, which was treated only with phlebotomy on three occasions.
6780149
 MALE Middle Aged
Twelve-year remission of polycythemia vera following Hodgkin's disease and chemotherapy.
Stolinsky DC.
CA Cancer J Clin. 1981;31(1):57-60.
The association of polycythemia vera and acute leukemia is well known, but the author is unaware of prior reports of polycythemia vera and Hodgkin's disease concurrent in the same patient.
6780149
 MALE Middle Aged
Twelve-year remission of polycythemia vera following Hodgkin's disease and chemotherapy.
Stolinsky DC.
CA Cancer J Clin. 1981;31(1):57-60.
The association of polycythemia vera and acute leukemia is well known, but the author is unaware of prior reports of polycythemia vera and Hodgkin's disease concurrent in the same patient.
6248977
 MIXED_SAMPLE Adult
[Pyoderma gangrenosum and chronic myeloid leukemia. Two new cases (author's transl)].
Chevrant-Breton J, Verger JP, Queffeulou F, Leblay R.
Sem Hop. 1980;56(17-18):897-9.
It seems to have a bad prognosis in myeloid leukemia as in polycythemia vera, in which it appears lately as an evolution to myelofibrosis or acute leukemia transformation.
272208
 MALE Middle Aged
Conversion of polycythemia vera to refractory anemia with hyperplastic bone marrow.
Mitrou PS, Fischer M, Krehan L, Martin H.
Blut. 1978;36(1):41-5.
The prognosis in cases of refractory anemia with hyperplastic bone marrow following polycythemia vera is, independent of the subsequent acute leukemia, invariably terminal.
407763
 OTHER
Acquired pyruvate kinase deficiency with hemolysis in preleukemia.
Helmstadter V, Arnold H, Blume KG, Uhl N, Hunstein W.
Acta Haematol. 1977;57(6):339-43.
acute leukemia, sideroblastic anemia, polycythemia vera.
1192363
 FEMALE Middle Aged
Abnormalities of chromosome 1 in myeloproliferative disorders.
Rowley JD.
Cancer. 1975;36(5):1748-57.
Patient 1 had a brief period of anemia and thrombocytopenia which preceded a terminal acute leukemia; Patient 2 had polycythemia vera (P.V.)
1098766
 MIXED_SAMPLE Middle Aged
Chromosome studies in acute leukemias developing in patients with multiple myeloma.
Hossfeld DK, Holland JF, Cooper RG, Ellison RR.
Cancer Res. 1975;35(10):2808-13.
This is supported by chromosomal findings in patients with acute leukemia following polycythemia vera and Hodgkin's disease; practically all of the leukemias have been aneuploid.