Prader-Willi syndrome

Prader-Willi syndrome is a rare genetic disorder characterized by hypothalamic-pituitary abnormalities with severe hypotonia during the neonatal period and first two years of life and the onset of hyperphagia with a risk of morbid obesity during infancy and adulthood, learning difficulties and behavioral problems or severe psychiatric problems.

Downslanted palpebral fissures

The palpebral fissure inclination is more than two standard deviations below the mean.


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PMID (PMCID)