Proteus syndrome

Proteus syndrome (PS) is a very rare and complex hamartomatous overgrowth disorder characterized by progressive overgrowth of the skeleton, skin, adipose, and central nervous systems.

Downslanted palpebral fissures

The palpebral fissure inclination is more than two standard deviations below the mean.


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PMID (PMCID)
28002528
 FEMALE Middle Aged
Redundant plantar skin folds.
Damian LO, Simon SP, Felea I, Botar-Jid C, Stancu B, Rogojan L, Pamfil CA, Albu A, Rednic S.
Rom J Morphol Embryol. 2016;57(3):1085-1088.
However, a small cerebriform plantar collagenoma, along with discrete dysmorphic features with downslanting palpebral fissures and mild right ptosis, second and third syndactyly and a larger first right toe since childhood, and early-onset bilateral ovarian cystadenoma, suggested a minimal Proteus syndrome.