Polyarteritis nodosa

Polyarteritis nodosa (PAN) is a rare, clinically heterogeneous, rheumatologic disease characterized by necrotizing inflammatory lesions affecting small- and medium-sized blood vessels. PAN most commonly affects skin, joints, peripheral nerves, the gut, and the kidney.

Splenomegaly

Abnormal increased size of the spleen.


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PMID (PMCID)
6134486
 FEMALE Adult
[Gougerot-Sjogren syndrome, periarteritis nodosa, non-Hodgkin's lymphoplasmocytic lymphoma and acquired C4 deficiency].
Herreman G, Ferme I, Diebold J, Baviera E, Audouin J, Bazin C, Godeau P.
Ann Med Interne (Paris). 1983;134(1):19-25.
Four years later, periarteritis nodosa (PAN) with characteristic vascular lesions on muscle biopsy occurred simultaneously with lymphatic hyperplasia comprising splenomegaly and polyadenopathy.