Polyarteritis nodosa

Polyarteritis nodosa (PAN) is a rare, clinically heterogeneous, rheumatologic disease characterized by necrotizing inflammatory lesions affecting small- and medium-sized blood vessels. PAN most commonly affects skin, joints, peripheral nerves, the gut, and the kidney.

Granulomatosis

A granulomatous inflammation leading to multiple granuloma formation, which is a specific type of inflammation. A granuloma is a focal compact collection of inflammatory cells, mononuclear cells predominating, usually as a result of the persistence of a non-degradable product and of active cell mediated hypersensitivity.


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PMID (PMCID)
24237487
 MIXED_SAMPLE Adult
Uncommon presentations of primary systemic necrotizing vasculitides: the Great Masquerades.
Sharma A, Gopalakrishan D, Nada R, Kumar S, Dogra S, Aggarwal MM, Gupta R, Minz RW, Kakkar N, Vashishtha RK, Singh S.
Int J Rheum Dis. 2014;17(5):562-72.
These included 45 patients with granulomatosis with polyangiitis (Wegener's granulomatosis), 18 with classic polyarteritis nodosa, five with microscopic polyangiitis, four with Churg-Strauss syndrome and seven with unclassifiable vasculitis.
24237487
 MIXED_SAMPLE Adult
Uncommon presentations of primary systemic necrotizing vasculitides: the Great Masquerades.
Sharma A, Gopalakrishan D, Nada R, Kumar S, Dogra S, Aggarwal MM, Gupta R, Minz RW, Kakkar N, Vashishtha RK, Singh S.
Int J Rheum Dis. 2014;17(5):562-72.
All patients diagnosed as having systemic vasculitides and classified as having granulomatosis with polyangiitis (Wegener's granulomatosis), classic polyarteritis nodosa, microscopic polyangiitis and unclassifiable vasculitis according to EMEA consensus methodology and followed up prospectively from June 2007 to December, 2011 were included.
24237487
 MIXED_SAMPLE Adult
Uncommon presentations of primary systemic necrotizing vasculitides: the Great Masquerades.
Sharma A, Gopalakrishan D, Nada R, Kumar S, Dogra S, Aggarwal MM, Gupta R, Minz RW, Kakkar N, Vashishtha RK, Singh S.
Int J Rheum Dis. 2014;17(5):562-72.
Such uncommon presentations of granulomatosis with polyangiitis (Wegener's granulomatosis), classical polyarteritis nodosa and unclassifiable vasculitides are described here with the relevant review of literature.
23993305
 FEMALE
Peripheral ulcerative keratitis in association with sarcoidosis.
Harthan JS, Reeder RE.
Cont Lens Anterior Eye. 2013;36(6):313-7.
Peripheral ulcerative keratitis as a purely inflammatory entity is most commonly associated with collagen vascular diseases, including rheumatoid arthritis, polyarteritis nodosa, Wegener granulomatosis, systemic lupus erythematosus, and relapsing polychondritis.
23087285
 MALE Middle Aged
Vasculitides associated with haematological malignancies: a case-based review.
Gulati S, Patel NP, Swierczynski SL.
BMJ Case Rep. 2012;2012:.
Vasculitis syndromes associated with malignant disease include cutaneous leucocytoclastic vasculitis, polyarteritis nodosa, Churg-Strauss syndrome, microscopic polyangiitis, Wegener's granulomatosis and Henoch-Schonlein purpura.
22669529
 MALE Adult
Systemic vasculitis: a dual diagnosis?
Gil E, Lutalo P, D'Cruz D.
BMJ Case Rep. 2011;2011:.
The authors describe a 25-year-old male with systemic vasculitis fulfilling the American College of Rheumatology classification criteria for both granulomatosis with polyangiitis (Wegener's granulomatosis) and polyarteritis nodosa.
19459029
 FEMALE
Giant cell arteritis of the breast: a case report with a review of literatures.
Kadotani Y, Enoki Y, Itoi N, Kojima F, Kato G, Lee CJ.
Breast Cancer. 2010;17(3):225-32.
GCA of the breast occasionally mimics carcinoma, and its initial manifestations may be similar to those of other forms of vasculitis involving the breast, such as polyarteritis nodosa and Wegener granulomatosis.
19348348
 MIXED_SAMPLE Adult
[Renal changes in vasculitis: case report].
Galesic K, Morovic-Vergles J, Ljubanovic D.
Lijec Vjesn. 2009;131(1-2):4-9.
Renal biopsy was performed in 13 patients: 6 patients had microscopic polyangiitis, 4 Wegener's granulomatosis, 2 microscopic polyangiitis limited to the kidneys and 3 polyarteritis nodosa.
18324327
 FEMALE Adult
Autoimmune inflammatory myopathy in pregnancy.
Chopra S, Suri V, Bagga R, Thami MR, Sharma A, Bambery P.
Medscape J Med. 2008;10(1):17.
Autoimmune diseases such as systemic sclerosis, Wegner's granulomatosis, and polyarteritis nodosa are rarely seen in pregnancy, unlike systemic lupus erythematosus, whose association with pregnancy is well studied.
17219021
 MIXED_SAMPLE Child
Tumor necrosis factor blockade in the management of children with orphan diseases.
Brik R, Gepstein V, Shahar E, Goldsher D, Berkovitz D.
Clin Rheumatol. 2007;26(10):1783-5.
Preliminary data in adults suggest that several forms of vasculitis appear to be responsive to TNF antagonists-Behcet's disease, polyarteritis nodosa, Wegener granulomatosis, among others.
15769280
 MALE Adult
Alpha-1 anti-trypsin deficiency and Henoch-Schonlein purpura associated with anti-neutrophil cytoplasmic and anti-endothelial cell antibodies of immunoglobulin-A isotype.
Patterson CC, Ross P Jr, Pope-Harman AL, Knight DA, Magro CM.
J Cutan Pathol. 2005;32(4):300-6.
In addition to pulmonary and hepatic involvement, the disease has also been linked to an increased incidence of vasculitic syndromes and autoimmune diseases, including Wegener's granulomatosis, microscopic polyarteritis nodosa and Henoch-Schonlein purpura (HSP).
16371800
 FEMALE Middle Aged
Ureteral stenosis secondary to granulomatous vasculitis.
Freitas AP, Filho HC, Gonzalez F, Magalhaes F, Pazos MJ, Silva CR, Santiago MB.
J Clin Rheumatol. 2005;11(6):311-3.
They include polyarteritis nodosa (PAN), Churg-Strauss syndrome (CS), and Wegener granulomatosis (WG) that differ on type, size, and location of the involved vessels.
15540571
 FEMALE Middle Aged
Middle colic artery rupture in a patient with ANCA associated vasculitis: a case report.
Dutton-Gaddis JG, Oyekan TB, Haraway GD, Crapse FJ.
J Okla State Med Assoc. 2004;97(9):364-6.
Gastrointestinal complications are a rare manifestation, first described in polyarteritis nodosa and more recently noted in Wegener's granulomatosis.
12652233
 FEMALE Adult
Acute posterior multifocal placoid pigment epitheliopathy associated with a systemic necrotizing vasculitis.
Hsu CT, Harlan JB, Goldberg MF, Dunn JP.
Retina. 2003;23(1):64-8.
The authors present a case of acute posterior multifocal placoid pigment epitheliopathy (APMPPE) associated with a systemic necrotizing vasculitis with mixed features of Wegener granulomatosis and polyarteritis nodosa (PAN).
14708910
 MIXED_SAMPLE Adult
F-18-fluorodeoxyglucose positron emission tomography in diagnosis and follow-up of patients with different types of vasculitis.
Bleeker-Rovers CP, Bredie SJ, van der Meer JW, Corstens FH, Oyen WJ.
Neth J Med. 2003;61(10):323-9.
Fourteen patients were diagnosed with vasculitis (giant cell arteritis n = 5, polymyalgia rheumatica n = 2, polyarteritis nodosa n = 3, Takayasu n = 1, Churge-Strauss n = 1, Wegener's granulomatosis n = 1, vasculitis skin n = 1), two patients were diagnosed with fibromuscular dysplasia and one patient had media necrosis of the aorta.
12632606
 MIXED_SAMPLE Adult
[Bone marrow accumulation in gallium scintigraphy in patients with adult Still's disease].
Kanegae F, Tada Y, Ohta A, Ushiyama O, Suzuki N, Koarada S, Haruta Y, Yoshikai T, Nagasawa K.
Ryumachi. 2002;42(6):872-8.
These include 3 cases with ASD, and 1 case with systemic lupus erythematosus, polyarteritis nodosa, Wegener's granulomatosis and Sjogren's syndrome.
12360754
 MALE Middle Aged
[Cogan syndrome or sarcoidosis?].
Laude A, Fauchais AL, Hachulla E, Viget N, Lambert M, Michon-Pasturel U, Queyrel V, Hatron PY, Devulder B.
Rev Med Interne. 2002;23(8):720-3.
Based on Cogan's diagnostic criteria, Cogan's syndrome may be part of other systemic diseases, as polyarteritis nodosa or Wegener's granulomatosis.
11817116
 FEMALE Adult
[Ophthalmologic manifestations of systemic vasculitis: report of six cases and review of the literature].
Delarbre X, Andre M, Dalens H, Delevaux I, Lhoste-Trouilloud A, Tridon A, Schmidt J, Chanet V, Piette JC, Aumaitre O.
Rev Med Interne. 2001;22(11):1039-48.
Our patients suffered from Wegener's granulomatosis (four cases), periarteritis nodosa and Churg-Strauss syndrome.
14635319
 MIXED_SAMPLE Middle Aged
Temporal concurrence of vasculitis and cancer: a report of 12 cases.
Hutson TE, Hoffman GS.
Arthritis Care Res. 2000;13(6):417-23.
Other vasculitides included giant cell arteritis (n = 2), polyarteritis nodosa (n = 2), and Wegener's granulomatosis (n = 1).
9616852
 FEMALE
Coronary artery inflammation and thrombosis in Wegener's granulomatosis-polyarteritis nodosa overlap syndrome.
Morbini P, Dal Bello B, Arbustini E.
G Ital Cardiol. 1998;28(4):377-82.
Coronary artery inflammation and thrombosis in Wegener's granulomatosis-polyarteritis nodosa overlap syndrome.