Q fever

Q fever, caused by <i>Coxiella burnetii</i>, is a bacterial zoonosis with a wide clinical spectrum that can be life-threatening and, in some cases, can become chronic.

Granuloma

A compact, organized collection of mature mononuclear phagocytes, which may be but is not necessarily accompanied by accessory features such as necrosis.


Total: 27

                       


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PMID (PMCID)
26919849
 MALE Adult
[Q fever : A rare differential diagnosis of granulomatous disease].
Hippe S, Kellner N, Seliger G, Wiechmann V, Grunewald T.
Pathologe. 2016;37(3):269-74.
The bone marrow biopsy revealed so-called doughnut granulomas, which are not pathognomonic but a typical finding in Q fever.
24900046
 OTHER
A Case of Acute Q Fever Hepatitis Diagnosed by F-18 FDG PET/CT.
Oh M, Baek S, Lee SO, Yu E, Ryu JS.
Nucl Med Mol Imaging. 2012;46(2):125-8.
A liver biopsy then revealed fibrin-ring granulomas typically seen in Q fever.
23010400
 MALE Adult
[Q fever: bone marrow characteristic granuloma].
Szablewski V, Costes V, Rousset T, Mania E, El Aoufi N.
Ann Pathol. 2012;32(4):263-6.
[Q fever: bone marrow characteristic granuloma].
23010400
 MALE Adult
[Q fever: bone marrow characteristic granuloma].
Szablewski V, Costes V, Rousset T, Mania E, El Aoufi N.
Ann Pathol. 2012;32(4):263-6.
Bone marrow biopsy showed the characteristic "doughnut" granuloma, suggesting a Q fever.
23010400
 MALE Adult
[Q fever: bone marrow characteristic granuloma].
Szablewski V, Costes V, Rousset T, Mania E, El Aoufi N.
Ann Pathol. 2012;32(4):263-6.
Histological studies of Q fever based on infected organs biopsies (liver and bone marrow) have demonstrated a distinctive type of granuloma, typically appearing as a "doughnut" granuloma, characterized by a central clean space surrounded by inflammatory cells and rimmed with an eosinophilic fibrinoid material.
23010400
 MALE Adult
[Q fever: bone marrow characteristic granuloma].
Szablewski V, Costes V, Rousset T, Mania E, El Aoufi N.
Ann Pathol. 2012;32(4):263-6.
Histological studies of Q fever based on infected organs biopsies (liver and bone marrow) have demonstrated a distinctive type of granuloma, typically appearing as a "doughnut" granuloma, characterized by a central clean space surrounded by inflammatory cells and rimmed with an eosinophilic fibrinoid material.
20071129
 MALE
Fibrin ring granulomas in Rickettsia typhi infection.
Restrepo MI, Vasquez EM, Echeverri C, Fiebelkorn KR, Anstead GM.
Diagn Microbiol Infect Dis. 2010;66(3):322-5.
A bone marrow biopsy showed fibrin ring granulomas, and 2 rickettsial serologic panels were positive for Rickettsia typhi infection and negative for Q fever.
17520520
 MALE Middle Aged
Fibrin ring granuloma in chronic hepatitis C: virus-related vasculitis and/or immune complex disease?
Glazer E, Ejaz A, Coley CJ 2nd, Bednarek K, Theise ND.
Semin Liver Dis. 2007;27(2):227-30.
Fibrin ring granulomas have been described in Q fever; in viral infections such as cytomegalovirus, Epstein-Barr virus, and hepatitis A virus; and in other conditions.
15811266
 MALE Adult
[Acalculous cholecystitis: an uncommon form of presentation of Q fever].
Gonzalez Delgado L, Lopez Larramona G, Santolaria Piedrafita S, Garcia Prats D, Ferrero Cancer M, Montoro Huguet M.
Gastroenterol Hepatol. 2005;28(4):232-6.
Characteristic "doughnut" epithelioid granulomas were observed, suggesting a diagnosis of granulomatous hepatitis caused by Q fever, which was confirmed by serological methods.
10943102
 MALE Adult
[Bone marrow granulomatosis in Q-fever].
Rexroth G, Rosch W, Altmannsberger M.
Med Klin (Munich). 2000;95(7):404-8.
In a 29-year-old patient with undulating fever of 3 months duration solely the demonstration of bone marrow fibrin ring granulomas led to the diagnosis of protracted Q-fever.
10549097
 MALE Middle Aged
[Sheep, chills and "doughnut granuloma"--an atypical course of Coxiella infection].
Erhardt A, Jablonowski H, Eick-Kerssenbrock M, Thomas L, Reinecke D, Haussinger D.
Z Gastroenterol. 1999;37(10):1019-23.
In Q fever with atypical clinical and serological presentation the screening of blood cells for inclusion bodies and liver or bone marrow tissue for granulomas may be important for establishing the diagnosis.
9504075
 MALE Middle Aged
[Granulomatous hepatitis caused by Q fever].
Gonzalez-Canudas JA, Vega B, Nellen-Hummel H, Lisker-Halpert A, Laredo-Sanchez F.
Gac Med Mex. 1997;133(5):475-7.
We inform of one case of fever and characteristic hepatic granuloma in which the final diagnosis was Q fever.
8514044
 MALE
Hepatic fibrin-ring granulomas in giant cell arteritis.
de Bayser L, Roblot P, Ramassamy A, Silvain C, Levillain P, Becq-Giraudon B.
Gastroenterology. 1993;105(1):272-3.
Other diseases usually associated with fibrin-ring granulomas in liver, such as Q fever, cytomegalovirus hepatitis, infectious mononucleosis, Hodgkin's disease, non-Hodgkin's lymphoma, allopurinol treatment, and visceral leishmaniasis, were ruled out.
1568415
 MALE Middle Aged
Fine-needle aspiration findings of the liver in a case of Q fever.
Greiner TC, Mitros FA, Stapleton J, Van Rybroek J.
Diagn Cytopathol. 1992;8(2):181-4.
Ring granulomas, which can be seen in an aspiration biopsy, should suggest the diagnosis of Q fever.
2774483
 FEMALE Adult
[Does Q fever hepatitis mimic acute alcoholic hepatitis?].
Dubois A, Perrin M, Pignodel C, Raffanel C, Balmes JL, Joujoux JM.
Ann Gastroenterol Hepatol (Paris). 1989;25(3):97-8.
The laboratory test mimic an acute alcoholic hepatitis; the presence of a clinical and radiological pulmonary affection led to the discovery of Q fever, the diagnosis of which was confirmed by serology and the discovery of a granuloma on histological examination of the liver.
3391373
 FEMALE
Chronic Q fever hepatitis complicated by extensive fibrosis.
Atienza P, Ramond MJ, Degott C, Lebrec D, Rueff B, Benhamou JP.
Gastroenterology. 1988;95(2):478-81.
We report the case of a patient suffering from chronic Q fever with nonspecific hepatitis and granulomas, in whom progressive development of extensive liver fibrosis was documented by repeated biopsies.
3391373
 FEMALE
Chronic Q fever hepatitis complicated by extensive fibrosis.
Atienza P, Ramond MJ, Degott C, Lebrec D, Rueff B, Benhamou JP.
Gastroenterology. 1988;95(2):478-81.
Liver involvement is common in acute and chronic Q fever and consists of nonspecific hepatitis and granulomas without fibrosis.
2836298
 MALE Middle Aged
Epstein-Barr virus infection and hepatic fibrin-ring granulomas.
Nenert M, Mavier P, Dubuc N, Deforges L, Zafrani ES.
Hum Pathol. 1988;19(5):608-10.
There was no evidence for Q fever, Hodgkin's disease, or allopurinol-induced hepatitis, which are recognized causes of hepatic fibrin-ring granulomas.
3611692
 MIXED_SAMPLE Middle Aged
The pathology of Q fever hepatitis. A case diagnosed by liver biopsy.
Westlake P, Price LM, Russell M, Kelly JK.
J Clin Gastroenterol. 1987;9(3):357-63.
The literature on the histopathology of the liver in both acute Q fever and Q fever endocarditis shows that none of the 220 cases of Q fever endocarditis, with one possible exception, had the characteristic granulomas of acute Q fever.
3611692
 MIXED_SAMPLE Middle Aged
The pathology of Q fever hepatitis. A case diagnosed by liver biopsy.
Westlake P, Price LM, Russell M, Kelly JK.
J Clin Gastroenterol. 1987;9(3):357-63.
A 52-year-old woman with fever and low grade hepatitis had Q fever, a diagnosis made by the characteristic granulomas, containing fibrin and vacuoles, on liver biopsy and confirmed by serology.