Retinoblastoma

A rare eye tumor disease representing the most common intraocular malignancy in children. It is a life threatening neoplasia but is potentially curable and it can be hereditary or non hereditary, unilateral or bilateral.

Leukemia

A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes.


Total: 6

                       


(per page)
PMID (PMCID)
21538823
(4517576)
 FEMALE Infant
Bi-allelic deletions within 13q14 and transient trisomy 21 with absence of GATA1s in pediatric acute megakaryoblastic leukemia.
Massaro SA, Bajaj R, Pashankar FD, Ornstein D, Gallagher PG, Krause DS, Li P.
Pediatr Blood Cancer. 2011;57(3):516-9.
Here we present a unique genetic profile that includes bi-allelic deletions within 13q14, where the retinoblastoma tumor suppressor gene (RB1) resides, as well as isolated trisomy 21 without a concomitant mutation in the hematopoietic transcription factor GATA1s and translocation (17;22), that does not involve the megakaryoblastic leukemia 1 (MKL1) gene located on chromosome 22.
18485932
 FEMALE Infant
Congenital mesoblastic nephroma rich from mitosis after in vitro fertilization: a case report.
Yigiter M, Arda IS, Kiyici H, Hicsonmez A.
J Pediatr Surg. 2008;43(5):E27-9.
Recently, various childhood tumors such as leukemia, neuroblastoma, hepatoblastoma, retinoblastoma, and central nervous system tumors in patients born after assisted conception have been reported.
12040434
 MIXED_SAMPLE Adult
Multiple cell cycle regulator alterations in Richter's transformation of chronic lymphocytic leukemia.
Cobo F, Martinez A, Pinyol M, Hernandez L, Gomez M, Bea S, Esteve J, Rozman M, Bosch F, Lopez-Guillermo A, Montserrat E, Campo E.
Leukemia. 2002;16(6):1028-34.
To investigate the role of the cell cycle regulators p21(Waf1), p27(Kip1), retinoblastoma (Rb), and cyclin D1 in Richter's transformation of chronic lymphocytic leukemia (CLL), we analyzed 19 CLL and eight Richter's syndrome (RS) tumors, previously characterized for p53 and ARF/INK4a abnormalities.
9689935
 FEMALE
Unilateral retinoblastoma with acquired monosomy 7 and secondary acute myelomonocytic leukemia.
Bayar E, Robinson MG, Kurczynski TW.
Cancer Genet Cytogenet. 1998;105(1):79-82.
We report here a case of treatment-related leukemia (secondary leukemia) with acquired monosomy 7, in a child with unilateral retinoblastoma.
9689935
 FEMALE
Unilateral retinoblastoma with acquired monosomy 7 and secondary acute myelomonocytic leukemia.
Bayar E, Robinson MG, Kurczynski TW.
Cancer Genet Cytogenet. 1998;105(1):79-82.
We report here a case of treatment-related leukemia (secondary leukemia) with acquired monosomy 7, in a child with unilateral retinoblastoma.
3965104
 FEMALE
Acute non-lymphocytic leukemia following multimodality therapy for retinoblastoma.
White L, Ortega JA, Ying KL.
Cancer. 1985;55(3):496-8.
A child with unilateral non-genetic retinoblastoma who had received chemotherapy and radiation therapy and developed acute non-lymphocytic leukemia (ANLL) is reported.