Retinoblastoma

A rare eye tumor disease representing the most common intraocular malignancy in children. It is a life threatening neoplasia but is potentially curable and it can be hereditary or non hereditary, unilateral or bilateral.

Carcinoma

A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas (NCI Thesaurus).

Total: 21

(per page)

PMID (PMCID)
25891343	MALE
	Loss of e-cadherin and retinoblastoma genes in a case of urothelial carcinoma with scrotal metastasis.
	Norberg SM, Oros M, Manucha V, Eun D, Bilusic M. Can J Urol. 2015;22(2):7755-7.
	Loss of e-cadherin and retinoblastoma genes in a case of urothelial carcinoma with scrotal metastasis.
19157501	MIXED_SAMPLE	Infant
	Pediatric sinonasal neuroendocrine carcinoma after treatment of retinoblastoma.
	Franchi A, Sardi I, Cetica V, Buccoliero A, Giordano F, Mussa F, Genitori L, Oliveri G, Miracco C. Hum Pathol. 2009;40(5):750-5.
	We report 2 cases of secondary sinonasal malignancy arising in pediatric patients previously treated for retinoblastoma, with features of neuroendocrine carcinoma.
19157501	MIXED_SAMPLE	Infant
	Pediatric sinonasal neuroendocrine carcinoma after treatment of retinoblastoma.
	Franchi A, Sardi I, Cetica V, Buccoliero A, Giordano F, Mussa F, Genitori L, Oliveri G, Miracco C. Hum Pathol. 2009;40(5):750-5.
	Pediatric sinonasal neuroendocrine carcinoma after treatment of retinoblastoma.
16175083	FEMALE	Adult
	Abnormalities of the RB1 pathway in ovarian serous papillary carcinoma as determined by overexpression of the p16(INK4A) protein.
	Armes JE, Lourie R, de Silva M, Stamaratis G, Boyd A, Kumar B, Price G, Hyde S, Allen D, Grant P, Venter DJ. Int J Gynecol Pathol. 2005;24(4):363-8.
	Our data indicate that abnormalities in the retinoblastoma pathway, as determined by p16 overexpression, are common in serous papillary carcinomas and are probably an early event.
11486176	FEMALE	Adult
	Primary mammary small-cell carcinoma: a molecular analysis of 2 cases.
	Hoang MP, Maitra A, Gazdar AF, Albores-Saavedra J. Hum Pathol. 2001;32(7):753-7.
	Laser capture microdissection followed by loss of heterozygosity (LOH) analysis revealed identical molecular alterations at multiple chromosomal regions, including BRCA-1, BRCA-2, p53, and retinoblastoma gene loci, in 1 case of small-cell carcinoma and its adjacent intraductal component.
11382640	MALE	Infant
	Sebaceous carcinoma of the eyelid associated with retinoblastoma.
	Kivela T, Asko-Seljavaara S, Pihkala U, Hovi L, Heikkonen J. Ophthalmology. 2001;108(6):1124-8.
	To analyze the association between retinoblastoma (Rb) and sebaceous carcinoma (SC) of the eyelid to improve surveillance of survivors of RB: Case report and systematic literature review.
11382640	MALE	Infant
	Sebaceous carcinoma of the eyelid associated with retinoblastoma.
	Kivela T, Asko-Seljavaara S, Pihkala U, Hovi L, Heikkonen J. Ophthalmology. 2001;108(6):1124-8.
	Sebaceous carcinoma of the eyelid associated with retinoblastoma.
9578885	FEMALE	Adult
	Multiple malignancies in a patient with bilateral retinoblastoma.
	Ceha HM, Balm AJ, de Jong D, van 't Veer LJ. J Laryngol Otol. 1998;112(2):189-92.
	A case is presented of a patient with bilateral retinoblastoma, treated at infancy with surgery, chemotherapy and radiotherapy, who subsequently developed at least four additional histologically distinct malignancies: a Ewing sarcoma of the left fibula, two extraskeletal osteosarcomas of the left lower extremity, a mucoepidermoid carcinoma of the right parotid gland and a squamous cell carcinoma of the left paranasal cavity.
17171005	OTHER
	Anterior skull base surgery for secondary malignancies in retinoblastoma survivors: report of two cases.
	Ichimura K, Nibu K, Tanaka T, Takekoshi H, Sasaki T, Taniguchi M, Nakatsuka T. Skull Base Surg. 1997;7(1):39-41.
	We had two retinoblastoma survivors with secondary malignancies in the naso-ethmoidal complex, one a 21-year-old man with anaplastic carcinoma and the other a 16-year-old girl with malignant fibrous histiocytoma.
7569549	MIXED_SAMPLE	Infant
	[Second tumors in pediatric oncologic patients. Report of 5 cases].
	Jimenez M, Leon P, Castro L, Azcona C, Sierrasesumaga L. Rev Med Univ Navarra. 1995;40(2):72-7.
	The second tumors observed were: one patient with malignant fibrous histiocytoma of the orbit after treatment bilateral retinoblastoma; one patient with multifocal osteosarcoma after cerebelli medullo-blastoma; one patient with Ewing's sarcoma of the fibula after neuroblastoma of the adrenal gland; one case of carcinoma of the thyroid gland after osteosarcoma of the femur and one patient with acute lymphoblastic leukemia after been treated of osteosarcoma of the femur.
2224792	MIXED_SAMPLE	Infant
	Possible involvement of the retinoblastoma gene in undifferentiated sinonasal carcinoma.
	Greger V, Schirmacher P, Bohl J, Bornemann A, Hurter T, Passarge E, Horsthemke B. Cancer. 1990;66(9):1954-9.
	Possible involvement of the retinoblastoma gene in undifferentiated sinonasal carcinoma.
2224792	MIXED_SAMPLE	Infant
	Possible involvement of the retinoblastoma gene in undifferentiated sinonasal carcinoma.
	Greger V, Schirmacher P, Bohl J, Bornemann A, Hurter T, Passarge E, Horsthemke B. Cancer. 1990;66(9):1954-9.
	The authors studied a 38-year-old patient with sinonasal undifferentiated carcinoma (SNUC) who had been treated for bilateral retinoblastoma by enucleation (left eye) and irradiation (right eye), respectively.
2760525	MALE	Child
	Second primary tumour following retinoblastoma.
	Berridge DC, Hitchcock A, Bradley PJ, Kapila L. J Laryngol Otol. 1989;103(7):690-1.
	The clinical association between retinoblastoma and mucoepidermoid carcinoma of the submandibular gland has not been previously reported.
3480957	MIXED_SAMPLE	Child
	Malignant melanoma in families of children with osteosarcoma, chondrosarcoma, and adrenal cortical carcinoma.
	Hartley AL, Birch JM, Marsden HB, Harris M. J Med Genet. 1987;24(11):664-8.
	The association between certain childhood malignancies (adrenal cortical carcinoma, osteosarcoma, chondrosarcoma, retinoblastoma) and malignant melanoma is discussed and it is proposed that in certain families malignant melanoma may be another manifestation of the same gene defect which results in susceptibility to tumours characteristic of the SBLA cancer family syndrome.
7136524	FEMALE
	Epithelial second malignant tumours in retinoblastoma survivors. A review and report of a case.
	Nuutinen J, Karja J, Sainio P. Acta Ophthalmol (Copenh). 1982;60(1):133-40.
	The first case of epidermoid carcinoma of the tongue found in a retinoblastoma survivors is described.
15633409	FEMALE	Infant
	Intracranial malignancy in patients with bilateral retinoblastoma.
	Donoso LA, Shields JA, Felberg NT, Martyn LJ, Truex RC Jr, D'Cruz CA. Retina. 1981;1(1):67-74.
	An antiserum derived against tissue cultured Y-79 retinoblastoma cells was utilized in order to examine the surface and cytoplasmic antigens of the two brain tumors, histopathologically diagnosed as an embryonal cell carcinoma (case 1), a pinealoblastoma (case 2), and one ocular retinoblastoma.
15633409	FEMALE	Infant
	Intracranial malignancy in patients with bilateral retinoblastoma.
	Donoso LA, Shields JA, Felberg NT, Martyn LJ, Truex RC Jr, D'Cruz CA. Retina. 1981;1(1):67-74.
	An antiserum derived against tissue cultured Y-79 retinoblastoma cells was utilized in order to examine the surface and cytoplasmic antigens of the two brain tumors, histopathologically diagnosed as an embryonal cell carcinoma (case 1), a pinealoblastoma (case 2), and one ocular retinoblastoma.
677667	MALE	Adult
	Presumed spontaneously regressed retinoblastoma.
	Benson WE, Cameron JD, Furgiuele FP, Felberg NT, Yanoff M. Ann Ophthalmol. 1978;10(7):897-9.
	A history of blindness in one eye since childhood, the fundus appearance of the other eye, and the family history of elevated plasma levels of carcinoembryonic (CEA) antigen and colorectal carcinoma led us to diagnose bilateral spontaneously regressed retinoblastoma.
686234	MIXED_SAMPLE	Infant
	Sebaceous carcinoma of the eyelid following radiation therapy.
	Lemos LB, Santa Cruz DJ, Baba N. Am J Surg Pathol. 1978;2(3):305-11.
	The carcinoma developed 11 years after curative radiation therapy for bilateral retinoblastoma.
264592	MIXED_SAMPLE	Child
	A new familial cancer syndrome? A spectrum of malignant and benign tumors including retinoblastoma, carcinoma of the bladder and other genitourinary tumors, thyroid adenoma, and a probable case of multifocal osteosarcoma.
	Chan H, Pratt CB. J Natl Cancer Inst. 1977;58(2):205-7.
	The histologic variety of these tumors, the predominance of genitourinary carcinoma, the higher than expected frequency of tumor appearance over six generations, and the occurrence of malignant tumors in direct lineage suggest that the case of retinoblastoma followed by osteosarcoma is part of a familial cancer syndrome.