Sotos syndrome

Sotos syndrome is a rare multisystemic genetic disorder characterized by a typical facial appearance, overgrowth of the body in early life with macrocephaly, and mild to severe intellectual disability.

Leukemia

A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes.


Total: 2

                       


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PMID (PMCID)
20101679
 FEMALE
Acute lymphoblastic leukemia in Weaver syndrome.
Basel-Vanagaite L.
Am J Med Genet A. 2010;152A(2):383-6.
Patients with overgrowth syndromes have an increased frequency of tumors; the risk in Sotos syndrome patients has been estimated to be about 2-3%, with leukemia and lymphoma accounting for 44% of the malignancies.
15125616
 MIXED_SAMPLE Infant
Cancer in Sotos syndrome: report of a patient with acute myelocytic leukemia and review of the literature.
Al-Mulla N, Belgaumi AF, Teebi A.
J Pediatr Hematol Oncol. 2004;26(3):204-8.
Cancer in Sotos syndrome: report of a patient with acute myelocytic leukemia and review of the literature.