Hereditary spherocytosis

Hereditary spherocytosis is a congenital hemolytic anemia with a wide clinical spectrum (from symptom-free carriers to severe hemolysis) characterized by anemia, variable jaundice, splenomegaly and cholelithiasis.

Cholecystitis

The presence of inflammatory changes in the gallbladder.


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PMID (PMCID)
9168768
 FEMALE
Concomitant laparoscopic cholecystectomy and splenectomy for surgical management of hereditary spherocytosis.
Patton ML, Moss BE, Haith LR Jr, Shotwell BA, Milliner DH, Simeone MR, Kraut JD, Patton JN.
Am Surg. 1997;63(6):536-9.
In conclusion, we present a combined laparoscopic cholecystectomy and splenectomy for hereditary spherocytosis associated with splenomegaly, cholelithiasis, and cholecystitis.
413463
 MIXED_SAMPLE Middle Aged
Monoclonal gammopathy in hereditary spherocytosis: a possible pathogenetic relation.
Schafer AI, Miller JB, Lester EP, Bowers TK, Jacob HS.
Ann Intern Med. 1978;88(1):45-6.
We propose that the chronic reticuloendothelial stimulation due to extravascular hemolysis, possibly potentiated by the inflammation associated with cholelithiasis and cholecystitis, may foster neoplastic transformation of immunocytes in patients with hereditary spherocytosis, ultimately leading to the development of monoclonal gammopathy.