Hereditary spherocytosis

Hereditary spherocytosis is a congenital hemolytic anemia with a wide clinical spectrum (from symptom-free carriers to severe hemolysis) characterized by anemia, variable jaundice, splenomegaly and cholelithiasis.

Cirrhosis

A chronic disorder of the liver in which liver tissue becomes scarred and is partially replaced by regenerative nodules and fibrotic tissue resulting in loss of liver function.


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PMID (PMCID)
7350706
 MIXED_SAMPLE Child
Circulatory control of splenic hyperfunction in children with peripheral blood dyscrasia.
Witte CL, Corrigan JJ Jr, Witte MH, Van Wyck DB, O'Mara RE, Woolfenden JM.
Surg Gynecol Obstet. 1980;150(1):75-80.
While this procedure initially improved the peripheral blood values in five patients--two patients with hereditary spherocytosis, one patient with idiopathic thrombocytopenic purpura, one patient with pyruvate-kinase hemolytic anemia and one patient with posthepatitic cirrhosis and splenomegaly--the hematologic derangement gradually recurred in four, necessitating eventual splenectomy in two.