Hereditary spherocytosis

Hereditary spherocytosis is a congenital hemolytic anemia with a wide clinical spectrum (from symptom-free carriers to severe hemolysis) characterized by anemia, variable jaundice, splenomegaly and cholelithiasis.

Positive direct antiglobulin test

A positive result of the direct antiglobulin test (DAT), a method of demonstrating the presence of antibody or complement bound to red blood cell (RBC) membranes by the use of anti-human globulin to form a visible agglutination reaction.

Total: 1

(per page)

PMID (PMCID)
20805704	MALE	Child
	[Flow-assisted differential diagnosis of hemolytic anemia with spherocytosis: a case report].
	Won DI. Korean J Lab Med. 2010;30(4):339-44.
	In this case, diagnosis was not determined because routine laboratory workups for hereditary spherocytosis yielded discrepant positive osmotic fragility test, positive direct antiglobulin test, and normal result in the red cell membrane protein sodium dodecyl succinimide polyacrylamide gel electrophoresis.