Hereditary spherocytosis

Hereditary spherocytosis is a congenital hemolytic anemia with a wide clinical spectrum (from symptom-free carriers to severe hemolysis) characterized by anemia, variable jaundice, splenomegaly and cholelithiasis.

Histiocytosis

An excessive number of histiocytes (tissue macrophages).


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PMID (PMCID)
1616240
 FEMALE Infant
[Skin manifestations revealing monocytic leukemia. A case report].
Cuny JF, Truchetet F, Levy M, Cabut S, Hennequin JP, Grandidier M.
Ann Pediatr (Paris). 1992;39(4):261-3.
These skin lesions are not specific of leukemia and other diagnoses should be considered including histiocytosis, neuroblastoma, and skin erythropoiesis (in Torch syndrome, hemolytic disease of the newborn, hereditary spherocytosis, and twin-to-twin transfusion syndrome).