Primary myelofibrosis

A rare myeloproliferative neoplasm characterized by stem-cell derived clonal over proliferation of mature myeloid lineages, such as erythrocytes, leukocytes, and megakaryocytes, with variable degrees of megakaryocyte atypia, associated with reticulin and/or collagen bone marrow fibrosis, osteosclerosis, ineffective erythropoiesis, angiogenesis, extramedullary hematopoiesis, and abnormal cytokine expression.

Muscle weakness

Reduced strength of muscles.


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PMID (PMCID)
16642932
 FEMALE
[A case of dermatomyositis associated with chronic idiopathic myelofibrosis].
Ito A, Umeda M, Koike T, Naruse S, Fujita N.
Rinsho Shinkeigaku. 2006;46(3):210-3.
A 74-year old woman had been suffering from chronic idiopathic myelofibrosis (CIMF) for three years before noticing skin rash and subsequent muscle weakness.