Primary myelofibrosis

A rare myeloproliferative neoplasm characterized by stem-cell derived clonal over proliferation of mature myeloid lineages, such as erythrocytes, leukocytes, and megakaryocytes, with variable degrees of megakaryocyte atypia, associated with reticulin and/or collagen bone marrow fibrosis, osteosclerosis, ineffective erythropoiesis, angiogenesis, extramedullary hematopoiesis, and abnormal cytokine expression.

Subcutaneous nodule

Slightly elevated lesions on or in the skin with a diameter of over 5 mm.

Total: 2

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PMID (PMCID)
23618686	FEMALE	Adult
	A case report on a patient who presented with myelofibrosis, developed breast cancer with myeloid metaplasia, and finally showed immature NK-cell leukemia or AML without maturation with CD56 expression transformation in the pleura with extramedullary hematopoiesis: a 25-year course.
	Oka K, Nagayama R, Yonekawa N, Koyamatsu S, Mori N. Pathol Res Pract. 2013;209(5):319-22.
	This study reports a female patient who suffered from primary myelofibrosis at 38 years of age, breast cancer with myeloid metaplasia at 49 years of age, and pleural effusion and multiple subcutaneous nodules at 62 years of age.
7378277	MALE
	Myelofibrosis with skin lesions.
	Tagami H, Tashima M, Uehara N. Br J Dermatol. 1980;102(1):109-112.
	An elderly male patient with primary myelofibrosis developed many papules on the trunk and later numerous subcutaneous nodules on the face.