Primary myelofibrosis

A rare myeloproliferative neoplasm characterized by stem-cell derived clonal over proliferation of mature myeloid lineages, such as erythrocytes, leukocytes, and megakaryocytes, with variable degrees of megakaryocyte atypia, associated with reticulin and/or collagen bone marrow fibrosis, osteosclerosis, ineffective erythropoiesis, angiogenesis, extramedullary hematopoiesis, and abnormal cytokine expression.

Leukopenia

An abnormal decreased number of leukocytes in the blood.

Total: 1

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PMID (PMCID)
6680005	MIXED_SAMPLE
	[Idiopathic splenomegalic myelofibrosis. Report of 2 clinical cases].
	Grandis P. Ann Osp Maria Vittoria Torino. 1983;26(7-12):293-308.
	A description of the clinical and haematological features of splenomegalic idiopathic myelofibrosis is followed by the presentation of two personal cases, one with a classic picture of the advanced stage and marked, progressive anaemia, leukopenia, frank splenomegaly and renal alterations, the second in the initial stage, with liver and spleen enlargement, very marked thrombocytosis and high white and red cell counts.