Primary myelofibrosis

A rare myeloproliferative neoplasm characterized by stem-cell derived clonal over proliferation of mature myeloid lineages, such as erythrocytes, leukocytes, and megakaryocytes, with variable degrees of megakaryocyte atypia, associated with reticulin and/or collagen bone marrow fibrosis, osteosclerosis, ineffective erythropoiesis, angiogenesis, extramedullary hematopoiesis, and abnormal cytokine expression.

Thrombocytosis

Increased numbers of platelets in the peripheral blood.


Total: 8

                       


(per page)
PMID (PMCID)
28259826
 MALE Middle Aged
Medical Management of Extensive Arterial Thromboembolism in a Patient with Essential Thrombocythemia and Warfarin Failure.
Ahmed AK, Youssef A, Skeik N.
Ann Vasc Surg. 2017;42:306.e5-306.e10.
This group of disorders include essential thrombocythemia (ET), polycythemia vera (PV), chronic myeloid leukemia, and primary myelofibrosis (PMF), with the respective features of thrombocytosis, erythrocytosis, and bone marrow fibrosis.
11928616
 FEMALE Adult
[Successful treatment of primary myelofibrosis with thrombocytosis during pregnancy with alfa-interferon].
Gotic M, Cvetkovic M, Bozanovic T, Cemerikic V.
Srp Arh Celok Lek. 2001;129(11-12):304-8.
In conclusion, according to the clinical results of interferon-d in thrombocytosis and experimental studies which showed the absence of placental transfer of interferon-d, this therapy could be recommended to women with primary myelofibrosis who wish to have a baby.
11928616
 FEMALE Adult
[Successful treatment of primary myelofibrosis with thrombocytosis during pregnancy with alfa-interferon].
Gotic M, Cvetkovic M, Bozanovic T, Cemerikic V.
Srp Arh Celok Lek. 2001;129(11-12):304-8.
[Successful treatment of primary myelofibrosis with thrombocytosis during pregnancy with alfa-interferon].
10492088
 MIXED_SAMPLE Middle Aged
Thrombocytosis with sideroblastic erythropoiesis: a mixed myeloproliferative myelodysplastic syndrome.
Gupta R, Abdalla SH, Bain BJ.
Leuk Lymphoma. 1999;34(5-6):615-9.
Two such patients are reported, both having sideroblastic erythropoiesis and thrombocytosis and one sequentially developing features of atypical chronic myeloid leukaemia, idiopathic myelofibrosis and acute megakaryoblastic leukaemia.
6680005
 MIXED_SAMPLE
[Idiopathic splenomegalic myelofibrosis. Report of 2 clinical cases].
Grandis P.
Ann Osp Maria Vittoria Torino. 1983;26(7-12):293-308.
A description of the clinical and haematological features of splenomegalic idiopathic myelofibrosis is followed by the presentation of two personal cases, one with a classic picture of the advanced stage and marked, progressive anaemia, leukopenia, frank splenomegaly and renal alterations, the second in the initial stage, with liver and spleen enlargement, very marked thrombocytosis and high white and red cell counts.
7283566
 FEMALE
Left ventricular mural thrombus in a patient with thrombocytosis and agnogenic myeloid metaplasia.
Baker KM, Hess CE, Ayers CR, Johns DW, Mentzer RM, Wellsons HA, Taylor GJ, Martin RP.
Arch Intern Med. 1981;141(11):1527-9.
A patient had thrombocytosis secondary to agnogenic myeloid metaplasia and a left ventricular mural thrombus developed in the absence of clinical or laboratory evidence of old or coronary angiogram and left ventricular function.
7283566
 FEMALE
Left ventricular mural thrombus in a patient with thrombocytosis and agnogenic myeloid metaplasia.
Baker KM, Hess CE, Ayers CR, Johns DW, Mentzer RM, Wellsons HA, Taylor GJ, Martin RP.
Arch Intern Med. 1981;141(11):1527-9.
Left ventricular mural thrombus in a patient with thrombocytosis and agnogenic myeloid metaplasia.
7432153
 MIXED_SAMPLE Adult
Nodular regenerative hyperplasia of the liver in hematologic disorders: a possible response to obliterative portal venopathy. A morphometric study of nine cases with an hypothesis on the pathogenesis.
Wanless IR, Godwin TA, Allen F, Feder A.
Medicine (Baltimore). 1980;59(5):367-79.
Nodular regenerative hyperplasia was found in nine patients who had hematological disease including polycythemia vera, agnogenic myeloid metaplasia, primary thrombocythemia, rheumatoid arthritis with thrombocytosis, multiple myeloma, and erythrocytosis associated with polycystic renal disease.