Primary myelofibrosis

A rare myeloproliferative neoplasm characterized by stem-cell derived clonal over proliferation of mature myeloid lineages, such as erythrocytes, leukocytes, and megakaryocytes, with variable degrees of megakaryocyte atypia, associated with reticulin and/or collagen bone marrow fibrosis, osteosclerosis, ineffective erythropoiesis, angiogenesis, extramedullary hematopoiesis, and abnormal cytokine expression.

Anemia

A reduction in erythrocytes volume or hemoglobin concentration.


Total: 23

                      


(per page)
PMID (PMCID)
29317181
FEMALE Middle Aged
Extramedullary hematopoiesis involving the thyroid: A rare cytologic finding in otherwise healthy patients and review of literature.
Jan IS, Weng MH, Wang CY, Chang TC, Shih SR.
J Formos Med Assoc. 2018;117(12):1108-1114.
Four patients had primary myelofibrosis, and one had chronic anemia.
29618692
MALE
[Transfusion independence achieved with pomalidomide therapy in a patient with primary myelofibrosis].
Edahiro Y, Gotoh A, Inano T, Tsutsui M, Tsukune Y, Yasuda H, Komatsu N.
Rinsho Ketsueki. 2018;59(3):323-325.
Primary myelofibrosis (PMF) is commonly associated with anemia.
27628559
MALE
[Zoledronic Acid Administration is Effective for Hematopoiesis Management in a Patient with Primary Myelofibrosis].
Sugama Y, Kuroda H, Horiguchi H, Yamauchi N, Sato K, Yamada M, Hamaguchi K, Nakamura H, Abe T, Fujii S, Maeda M, Fujita M, Koguma M, Koguma T, Kato J.
Gan To Kagaku Ryoho. 2016;43(9):1131-4.
An 80-year-old man received a diagnosis of anemia and a decreased platelet count from his physician in 2008, and was referred to our department where primary myelofibrosis was diagnosed.The patient was classified into the lower risk group according to the International Prognostic Scoring System(IPSS), and was followed up without treatment.In June 2010, pancytopenia progressed, and the patient was reclassified into the higher risk group.Blood count did not increase with metenolone treatment, but increased with zoledronic acid(ZA)that he started receiving from January 2012.
23039051
(3515333)
MALE
Disseminated tuberculosis in a patient treated with a JAK2 selective inhibitor: a case report.
Colomba C, Rubino R, Siracusa L, Lalicata F, Trizzino M, Titone L, Tolomeo M.
BMC Res Notes. 2012;5:552.
Primary myelofibrosis is a myeloproliferative disorder characterized by bone marrow fibrosis, abnormal cytokine expression, splenomegaly and anemia.
22374528
MIXED_SAMPLE
[Marked improvement of anemia during treatment with deferasirox in patients with primary myelofibrosis and acute myeloid leukemia with myelodysplasia-related changes].
Matsuki E, Matsumoto K, Nakaya A, Yamane A, Kato J, Okamoto S.
Rinsho Ketsueki. 2012;53(1):78-82.
[Marked improvement of anemia during treatment with deferasirox in patients with primary myelofibrosis and acute myeloid leukemia with myelodysplasia-related changes].
21496873
MIXED_SAMPLE Infant, Newborn
Extramedullary hematopoiesis involving the central nervous system and surrounding structures.
Zherebitskiy V, Morales C, Del Bigio MR.
Hum Pathol. 2011;42(10):1524-30.
Most were incidental autopsy findings, usually microscopic collections of cells in the meninges or around blood vessels in the brain of infants (4 cases; age, 10 days to 5 months), in 1 young child (age, 6.5 years with anemia), and 1 elderly adult (age, 81 years with end-stage idiopathic myelofibrosis).
21617547
MALE Middle Aged
Reversal of transfusion dependence by tumor necrosis factor inhibitor treatment in a patient with concurrent rheumatoid arthritis and primary myelofibrosis.
Ong A, Quach H, Leech M.
J Clin Rheumatol. 2011;17(4):211-3.
We report a patient with seropositive rheumatoid arthritis with concurrent primary myelofibrosis, who had transfusion-dependent anemia and moderate thrombocytopenia that reversed during treatment with adalimumab.
20700988
FEMALE Adult
[Agnogenic myeloid metaplasia in pregnancy. Case report].
Manole I, Costachescu G, Aldea MJ, Gavrilut M, Dumitrascu I.
Rev Med Chir Soc Med Nat Iasi. 2010;114(2):465-9.
Idiopathic myelofibrosis is a rare myeloproliferative disorder characterized by excessive accumulation of connective tissue in the bone marrow in association with anemia, splenomegaly and extramedullary hematopoiesis.
20154501
MALE Middle Aged
[Successful treatment with reduced-intensity stem cell transplantation for primary myelofibrosis].
Ito S, Hagihara M, Motohashi K, Maruta A, Ishigatsubo Y, Gomi S, Kanamori H.
Gan To Kagaku Ryoho. 2010;37(2):351-3.
A 60-year-old man was found to have anemia and leukocytosis from a health examination, and diagnosed with primary myelofibrosis (PMF).
18224414
FEMALE Middle Aged
Dramatic remission of anemia after thymectomy in a patient of idiopathic myelofibrosis with thymoma.
Shih YY, Hsiao LT, Yang CF, Wu YC, Chiou TJ.
Int J Hematol. 2008;87(1):56-9.
Anemia is one of the characteristics of idiopathic myelofibrosis (IMF), and malignant thymoma is usually associated with various hematologic disorders, including anemia, pancytopenia, and hypogammaglobulinemia.
18224414
FEMALE Middle Aged
Dramatic remission of anemia after thymectomy in a patient of idiopathic myelofibrosis with thymoma.
Shih YY, Hsiao LT, Yang CF, Wu YC, Chiou TJ.
Int J Hematol. 2008;87(1):56-9.
Anemia is one of the characteristics of idiopathic myelofibrosis (IMF), and malignant thymoma is usually associated with various hematologic disorders, including anemia, pancytopenia, and hypogammaglobulinemia.
18224414
FEMALE Middle Aged
Dramatic remission of anemia after thymectomy in a patient of idiopathic myelofibrosis with thymoma.
Shih YY, Hsiao LT, Yang CF, Wu YC, Chiou TJ.
Int J Hematol. 2008;87(1):56-9.
Dramatic remission of anemia after thymectomy in a patient of idiopathic myelofibrosis with thymoma.
16738896
MALE Middle Aged
Extramedullary hematopoiesis mimicking acute appendicitis: a rare complication of idiopathic myelofibrosis.
Elpek GO, Bozova S, Erdogan G, Temizkan K, Ogus M.
Virchows Arch. 2006;449(2):258-61.
We report a case with a previous history of idiopathic myelofibrosis, which presented with clinical findings of acute appendicitis that necessitate appendectomy after the relief of his anemia.
16321815
MALE
Agnogenic myeloid metaplasia with pulmonary hematopoiesis.
Boula A, Mantadakis E, Xilouri I, Foudoulakis A, Samonis G.
Hematology. 2005;10(6):501-3.
Agnogenic myeloid metaplasia (AMM) is characterized by bone marrow fibrosis, splenomegaly and leukoerythroblastic anemia and is frequently accompanied by extramedullary hematopoiesis (EMH).
12953130
FEMALE Adult
FLAG chemotherapy followed by allogeneic stem cell transplant using nonmyeloablative conditioning induces regression of myelofibrosis with myeloid metaplasia.
Tanner ML, Hoh CK, Bashey A, Holman P, Sun C, Broome HE, Lane T, Ball ED, Carrier E.
Bone Marrow Transplant. 2003;32(6):581-5.
A 38-year-old woman with agnogenic myeloid metaplasia complicated by the poor prognostic factors of severe osteosclerosis, prominent hepatosplenomegaly, and profound anemia was treated with FLAG chemotherapy to decrease her organomegaly before undergoing a nonmyeloablative allogeneic stem cell transplant from a matched-sibling donor.
15641221
MALE
Idiopathic myelofibrosis associated with renal extramedullary hematopoiesis and nephrotic syndrome: case report.
Liu TT, Chen JB, Chen WJ, Kuo CY, Lee CT.
Chang Gung Med J. 2000;23(3):169-74.
Herein, we report the case of a patient with idiopathic myelofibrosis who initially presented with hepatomegaly, anemia, and leukoerythroblastosis.
9718875
MIXED_SAMPLE Middle Aged
Effect of cyclosporin-A on anemia in idiopathic myelofibrosis.
Falcone A, Musto P, Carotenuto M.
Haematologica. 1998;83(7):665-6.
The recent report of Pietrasanta et al., describe an improvement of anemia in a case of idiopathic myelofibrosis (IMF) treated with cyclosporin-A (CyA) for Psoriatic skin lesions.
9718875
MIXED_SAMPLE Middle Aged
Effect of cyclosporin-A on anemia in idiopathic myelofibrosis.
Falcone A, Musto P, Carotenuto M.
Haematologica. 1998;83(7):665-6.
Effect of cyclosporin-A on anemia in idiopathic myelofibrosis.
9299862
MALE
Long-lasting effect of cyclosporin-A on anemia associated with idiopathic myelofibrosis.
Pietrasanta D, Clavio M, Vallebella E, Beltrami G, Cavaliere M, Gobbi M.
Haematologica. 1997;82(4):458-9.
Long-lasting effect of cyclosporin-A on anemia associated with idiopathic myelofibrosis.
9299862
MALE
Long-lasting effect of cyclosporin-A on anemia associated with idiopathic myelofibrosis.
Pietrasanta D, Clavio M, Vallebella E, Beltrami G, Cavaliere M, Gobbi M.
Haematologica. 1997;82(4):458-9.
Some reports suggest that immunologic mechanisms may play a role in the pathogenesis of anemia in idiopathic myelofibrosis (IMF).