Primary myelofibrosis

A rare myeloproliferative neoplasm characterized by stem-cell derived clonal over proliferation of mature myeloid lineages, such as erythrocytes, leukocytes, and megakaryocytes, with variable degrees of megakaryocyte atypia, associated with reticulin and/or collagen bone marrow fibrosis, osteosclerosis, ineffective erythropoiesis, angiogenesis, extramedullary hematopoiesis, and abnormal cytokine expression.

Leukemia

A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes.

Total: 26

(per page)

PMID (PMCID)
30562793	MALE	Middle Aged
	[A case of gout secondary to primary myelofibrosis].
	Ji LL, Hao YJ, Zhang ZL. Beijing Da Xue Xue Bao Yi Xue Ban. 2018;50(6):1117-1119.
	However,it is relatively rare to see gout associated with myeloproliferative diseases, including polycythemia vera, primary thrombocythemia, primary myelofibrosis and chronic myelocytic leukemia.
26592973	MALE	Middle Aged
	Pleural fluid extramedullary hematopoiesis case report with review of the literature.
	Koch M, Kurian EM. Diagn Cytopathol. 2016;44(1):41-4.
	We present a case of pleural fluid EMH in a patient with primary myelofibrosis and developing leukemia, with a review of the literature, prognostic implications and diagnostic challenges.
25305205	MALE
	Presence of calreticulin mutations in JAK2-negative polycythemia vera.
	Broseus J, Park JH, Carillo S, Hermouet S, Girodon F. Blood. 2014;124(26):3964-6.
	Calreticulin (CALR) mutations have been reported in Janus kinase 2 (JAK2)- and myeloproliferative leukemia (MPL)-negative essential thrombocythemia and primary myelofibrosis.
22658480	MALE	Middle Aged
	Transformation of primary myelofibrosis with 20q- in Philadelphia-positive acute lymphoblastic leukemia: case report and review of literature.
	Jurisic V, Colovic N, Terzic T, Djordjevic V, Colovic M. Pathol Res Pract. 2012;208(7):420-3.
	A 56-year-old male with chronic idiopathic myelofibrosis and cytogenetic finding of 20q- after a period of 10 months developed acute Philadelphia-positive lymphoblastic leukemia.
17669490	FEMALE	Adult
	Leukemias associated with Turner syndrome: report of three cases and review of the literature.
	Manola KN, Sambani C, Karakasis D, Kalliakosta G, Harhalakis N, Papaioannou M. Leuk Res. 2008;32(3):481-6.
	Here we report three TS patients with leukemia including one case of T-large granular lymphocyte leukemia (T-LGL), one rare case of coexistence of chronic lymphocytic leukemia (CLL) and idiopathic myelofibrosis (IMF) and one case of a patient with AML-M2 who received autologous stem cell transplantation (SCT).
17669490	FEMALE	Adult
	Leukemias associated with Turner syndrome: report of three cases and review of the literature.
	Manola KN, Sambani C, Karakasis D, Kalliakosta G, Harhalakis N, Papaioannou M. Leuk Res. 2008;32(3):481-6.
	Here we report three TS patients with leukemia including one case of T-large granular lymphocyte leukemia (T-LGL), one rare case of coexistence of chronic lymphocytic leukemia (CLL) and idiopathic myelofibrosis (IMF) and one case of a patient with AML-M2 who received autologous stem cell transplantation (SCT).
17963181	MIXED_SAMPLE	Child
	Ultrastructural characteristics of bone marrow in patients with hematological disease: a study of 13 cases.
	Ru YX, Zhao SX, Liu EB, Yang QY, Liu JH, Pang TX, Chen HS. Ultrastruct Pathol. 2007;31(5):327-32.
	In addition, excessive blood cell death in leukemia, apoptosis, and macrophage phagocytosis in myelodysplastic syndrome and polycythemia vera, as well as degranulation of eosinophils and megakaryocytes in chronic idiopathic myelofibrosis were predominant, respectively.
16880237	MIXED_SAMPLE	Middle Aged
	Hairy cell leukemia: an elusive but treatable disease.
	Wanko SO, de Castro C. Oncologist. 2006;11(7):780-9.
	It should be entertained as an alternative diagnosis in patients with cytopenias being assigned the diagnosis of aplastic anemia, hypoplastic myelodysplastic syndrome, atypical chronic lymphocytic leukemia, B-prolymphocytic leukemia, or idiopathic myelofibrosis.
16880237	MIXED_SAMPLE	Middle Aged
	Hairy cell leukemia: an elusive but treatable disease.
	Wanko SO, de Castro C. Oncologist. 2006;11(7):780-9.
	It should be entertained as an alternative diagnosis in patients with cytopenias being assigned the diagnosis of aplastic anemia, hypoplastic myelodysplastic syndrome, atypical chronic lymphocytic leukemia, B-prolymphocytic leukemia, or idiopathic myelofibrosis.
16403285	MIXED_SAMPLE	Middle Aged
	Morphological study on the megakaryocytes with nuclear extrusion and nucleocytoplasmic separation in four cases.
	Lu XG, Zhu L, Wang WQ, Zhang XH, Zhao XY, Xu GB, Xu Z. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2005;13(6):1082-5.
	To investigate the morphological changes of megakaryocytes with nuclear extrusion and nucleocytoplasmic separation, the morphological characteristics of megakaryocytes in peripheral blood films, bone marrow smears, and bone marrow biopsies from 4 newly diagnosed patients with primary myelofibrosis (PMF), myelodysplastic syndrome (MDS), myeloblastic leukemia with maturation (M(2)) and erythroleukemia (M(6)) were studied by using light microscope.
15481449	MALE	Adult
	Primary myelofibrosis terminated in basophilic leukemia and successful allogeneic bone marrow transplantation.
	Sugimoto N, Ishikawa T, Gotoh S, Shinzato I, Matsushita A, Nagai K, Ohgoh N, Takahashi T. Int J Hematol. 2004;80(2):183-5.
	Transformation of primary myelofibrosis (PMF) to basophilic leukemia is very rare.
15481449	MALE	Adult
	Primary myelofibrosis terminated in basophilic leukemia and successful allogeneic bone marrow transplantation.
	Sugimoto N, Ishikawa T, Gotoh S, Shinzato I, Matsushita A, Nagai K, Ohgoh N, Takahashi T. Int J Hematol. 2004;80(2):183-5.
	Primary myelofibrosis terminated in basophilic leukemia and successful allogeneic bone marrow transplantation.
10980637	FEMALE
	A case of chronic lymphocytic leukemia overwhelmed by rapidly progressive idiopathic myelofibrosis.
	Nieto LH, Raya Sanchez JM, Arguelles HA, Brito Barroso ML, Gonzalez BG. Haematologica. 2000;85(9):973-7.
	A case of chronic lymphocytic leukemia overwhelmed by rapidly progressive idiopathic myelofibrosis.
9680115	MIXED_SAMPLE	Adult
	N-RAS oncogene mutations in patients with agnogenic myeloid metaplasia in leukemic transformation.
	Wang JC, Chen C. Leuk Res. 1998;22(7):639-43.
	From 5% to 20% of patients with agnogenic myeloid metaplasia (AMM) will evolve into a terminal leukemic phase; N-RAS gene mutations are the most common gene abnormalities detected in patients with leukemia.
9787320	FEMALE	Child
	Successful treatment of essential thrombocythemia evolving into agnogenic myeloid metaplasia with interferon-alpha.
	Kikawa Y, Fukumoto Y, Obata K, Tamura S, Takeuchi M, Tanizawa A, Mayumi M. J Pediatr Hematol Oncol. 1998;20(5):463-6.
	Whether IFN-alpha therapy can prevent the progression of idiopathic myelofibrosis to leukemia has not yet been determined.
7783340	MALE
	[Transformation into chronic myelomonocytic leukemia in a patient with primary myelofibrosis associated with severe hypoplasia: report of an autopsy case].
	Yamazaki Y, Horiguchi-Yamada J, Ochi K, Nakada S, Nemoto T, Inaba S, Yamada H. Rinsho Ketsueki. 1995;36(4):347-52.
	It is known that major causes of death for patients with primary myelofibrosis are infection, bleeding, cardiac trouble and transformation to leukemia.
7688180	MALE	Adult
	CD7, CD34-positive stem cell leukemia arising in agnogenic myeloid metaplasia.
	Tasaka T, Nagai M, Murao S, Yamaguchi M, Kitanaka A, Sasaki K, Murata M, Tanaka T, Kuwabara H, Ikeda K, et al.. Am J Hematol. 1993;44(1):53-7.
	CD7, CD34-positive stem cell leukemia arising in agnogenic myeloid metaplasia.
2009512	MALE
	Trisomy 8 and an unbalanced t(5;17)(q11;p11) characterize two karyotypically independent clones in a case of idiopathic myelofibrosis evolving to acute nonlymphoid leukemia.
	Kerim S, Rege-Cambrin G, Scaravaglio P, Godio L, Saglio G, Aglietta M. Cancer Genet Cytogenet. 1991;52(1):63-9.
	In a patient with idiopathic myelofibrosis (MFI) that had progressed to acute nonlymphoid leukemia (ANLL) after a long-lasting cytotoxic treatment, we observed two karyotypically independent cell populations, one showing trisomy of chromosome 8 as the only anomaly and one with an unbalanced translocation t(5;17)(q11) resulting in partial monosomy of 5q and 17p.
2009512	MALE
	Trisomy 8 and an unbalanced t(5;17)(q11;p11) characterize two karyotypically independent clones in a case of idiopathic myelofibrosis evolving to acute nonlymphoid leukemia.
	Kerim S, Rege-Cambrin G, Scaravaglio P, Godio L, Saglio G, Aglietta M. Cancer Genet Cytogenet. 1991;52(1):63-9.
	Trisomy 8 and an unbalanced t(5;17)(q11;p11) characterize two karyotypically independent clones in a case of idiopathic myelofibrosis evolving to acute nonlymphoid leukemia.
2811498	MIXED_SAMPLE	Middle Aged
	[Beneficial effect of 1,25-dihydroxyvitamin D3 in the treatment of myelofibrosis].
	Palomera L, Garcia Diez I, Martinez R. Med Clin (Barc). 1989;93(7):265-8.
	Two cases of myelofibrosis are reported, one corresponding to a chronic idiopathic myelofibrosis and another to an acute myelofibrosis or megakaryoblastic leukemia (AMGL).