Primary myelofibrosis

A rare myeloproliferative neoplasm characterized by stem-cell derived clonal over proliferation of mature myeloid lineages, such as erythrocytes, leukocytes, and megakaryocytes, with variable degrees of megakaryocyte atypia, associated with reticulin and/or collagen bone marrow fibrosis, osteosclerosis, ineffective erythropoiesis, angiogenesis, extramedullary hematopoiesis, and abnormal cytokine expression.

Leukocytosis

An abnormal increase in the number of leukocytes in the blood.

Total: 4

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PMID (PMCID)
25519030	FEMALE
	Severe case of peripheral leukocytosis initially diagnosed as myelodysplastic syndrome/myeloproliferative neoplasm, unclassifiable, but possibly prefibrotic primary myelofibrosis.
	Ota S, Hiramatsu Y, Kondo E, Kasahara A, Takada S, Umena S, Noguchi T, Tanimoto M, Matsumura T. Acta Med Okayama. 2014;68(6):363-8.
	Severe case of peripheral leukocytosis initially diagnosed as myelodysplastic syndrome/myeloproliferative neoplasm, unclassifiable, but possibly prefibrotic primary myelofibrosis.
21393891	MIXED_SAMPLE	Middle Aged
	JAK2-positive Philadelphia-negative myeloproliferative neoplasms.
	Sharma A, Buxi G, Marwah S, Yadav R. Indian J Pathol Microbiol. 2011;54(1):117-20.
	Here are two cases which incidentally presented with splenomegaly and moderate leukocytosis, and were diagnosed as MPN-primary myelofibrosis (PMF) in prefibrotic phase and polycythemia vera (PV), respectively, using revised World Health Organization (WHO) 2008 criteria.
20154501	MALE	Middle Aged
	[Successful treatment with reduced-intensity stem cell transplantation for primary myelofibrosis].
	Ito S, Hagihara M, Motohashi K, Maruta A, Ishigatsubo Y, Gomi S, Kanamori H. Gan To Kagaku Ryoho. 2010;37(2):351-3.
	A 60-year-old man was found to have anemia and leukocytosis from a health examination, and diagnosed with primary myelofibrosis (PMF).
2232372	FEMALE	Middle Aged
	Primary myelofibrosis terminating in megakaryoblastic crisis.
	Kurashima K, Kawamura Y, Ohka T, Hayashi M, Matsuda T. Jpn J Med. 1990;29(2):226-9.
	The patient, a 62-year-old female, having had primary myelofibrosis for 13 years and a splenectomy 4 years before, was admitted because of high fever, hepatomegaly, thrombocythemia and leukocytosis.