Primary myelofibrosis

A rare myeloproliferative neoplasm characterized by stem-cell derived clonal over proliferation of mature myeloid lineages, such as erythrocytes, leukocytes, and megakaryocytes, with variable degrees of megakaryocyte atypia, associated with reticulin and/or collagen bone marrow fibrosis, osteosclerosis, ineffective erythropoiesis, angiogenesis, extramedullary hematopoiesis, and abnormal cytokine expression.

Extramedullary hematopoiesis

The process of hematopoiesis occurring outside of the bone marrow (in the liver, thymus, and spleen) in the postnatal organisms.

Total: 60

(per page)

PMID (PMCID)
27874969	FEMALE
	Idiopathic myelofibrosis accompanied by peritoneal extramedullary hematopoiesis presenting as refractory ascites in a dog.
	Rautenbach Y, Goddard A, Clift SJ. Vet Clin Pathol. 2017;46(1):46-53.
	Idiopathic myelofibrosis accompanied by peritoneal extramedullary hematopoiesis presenting as refractory ascites in a dog.
27874969	FEMALE
	Idiopathic myelofibrosis accompanied by peritoneal extramedullary hematopoiesis presenting as refractory ascites in a dog.
	Rautenbach Y, Goddard A, Clift SJ. Vet Clin Pathol. 2017;46(1):46-53.
	This case represents the first report of canine idiopathic myelofibrosis associated with peritoneal extramedullary hematopoiesis, resulting in refractory ascites.
29350220 (5715205)	OTHER
	Nephrotic syndrome in primary myelofibrosis with renal extramedullary hematopoiesis and glomerulopathy in the JAK inhibitor era.
	Del Sordo R, Brugnano R, Covarelli C, Fiorucci G, Falzetti F, Barbatelli G, Nunzi E, Sidoni A. Clin Nephrol Case Stud. 2017;5:70-77.
	Primary myelofibrosis (PMF) is an uncommon form of myeloproliferative neoplasm (MPN) characterized by a proliferation of predominantly megakaryocytes and granulocytes in the bone marrow that, in fully-developed disease, is associated with reactive deposition of fibrous connective tissue, extramedullary hematopoiesis (EMH), and splenomegaly.
28775247 (5551928)	MALE	Middle Aged
	Spinal Abscess Caused by Salmonella Bacteremia in a Patient with Primary Myelofibrosis.
	Fareed S, Nashwan AJ, Abu Jarir S, Husain A, Suliman DS, Ibrahim F, Moustafa A, Akhter MS, Yassin MA. Am J Case Rep. 2017;18:859-864.
	BACKGROUND In Primary Myelofibrosis (PMF; a clonal disorder arising from the neoplastic transformation of early hematopoietic stem cells) patients, spinal cord compression (SCC) is a common complication or even a presentation symptom due to extramedullary hematopoiesis (EMH).
26885416 (4739215)	OTHER
	Primary Myelofibrosis Presenting as Extramedullary Hematopoiesis in a Transplanted Liver Graft: Case Report and Review of the Literature.
	Mohyuddin GR, Yacoub A. Case Rep Hematol. 2016;2016:9515404.
	Primary Myelofibrosis Presenting as Extramedullary Hematopoiesis in a Transplanted Liver Graft: Case Report and Review of the Literature.
26185644 (4498858)	OTHER
	Nontuberculous mycobacterial infection in a patient with myelofibrosis: case report and concise review.
	Henriquez-Camacho C, Martinez-Barranco P, Velasco M, Villafuerte-Gutierrez P, Losa J. Clin Case Rep. 2015;3(6):438-41.
	A 70-year-old patient having massive refractory ascites in the course of idiopathic myelofibrosis was diagnosed of peritoneal extramedullary hematopoiesis and developed an overwhelming nontuberculous mycobacterial infection.
26358171	FEMALE	Middle Aged
	Role of Endothelin-1 in a Syndrome of Myelofibrosis and Osteosclerosis.
	Yachoui R, Kristianto J, Sitwala K, Blank RD. J Clin Endocrinol Metab. 2015;100(11):3971-4.
	Primary myelofibrosis is one of the chronic myeloproliferative disorders characterized by bone marrow fibrosis associated with extramedullary hematopoiesis and osteosclerosis.
25206301	MALE	Middle Aged
	Intestinal obstruction caused by extramedullary hematopoiesis and ascites in primary myelofibrosis.
	Wei XQ, Zheng ZH, Jin Y, Tao J, Abassa KK, Wen ZF, Shao CK, Wei HB, Wu B. World J Gastroenterol. 2014;20(33):11921-6.
	Intestinal obstruction caused by extramedullary hematopoiesis and ascites in primary myelofibrosis.
25741217 (4347479)	OTHER
	Translocation t(3;12)(q26;q21) in JAK2(V617F) Point Mutation Negative Chronic Idiopathic Myelofibrosis: A Case Report.
	Meanovic S, ahovic H, Peric M. Balkan J Med Genet. 2014;17(1):63-8.
	Chronic idiopathic myelofibrosis (CIMF) is a stem cell defect characterized by splenomegaly with multiorgan extramedullary hematopoiesis, immature peripheral blood granulocytes and erythrocytes and progressive bone marrow fibrosis.
23117264	MIXED_SAMPLE	Middle Aged
	Splenic irradiation as a component of a reduced-intensity conditioning regimen for hematopoietic stem cell transplantation in myelofibrosis with massive splenomegaly.
	Ito T, Akagi K, Kondo T, Kawabata H, Ichinohe T, Takaori-Kondo A. Tohoku J Exp Med. 2012;228(4):295-9.
	Primary myelofibrosis is a hematologic neoplasm characterized by bone marrow fibrosis and extramedullary hematopoiesis.
22722458	MALE
	Transjugular intrahepatic porto-systemic stent-shunt for therapy of bleeding esophageal varices due to extramedullary hematopoiesis in primary myelofibrosis: a case report.
	Phillip V, Berger H, Straub M, Saugel B, Treiber M, Einwachter H, Schmid RM, Huber W. Onkologie. 2012;35(6):368-71.
	Transjugular intrahepatic porto-systemic stent-shunt for therapy of bleeding esophageal varices due to extramedullary hematopoiesis in primary myelofibrosis: a case report.
22722458	MALE
	Transjugular intrahepatic porto-systemic stent-shunt for therapy of bleeding esophageal varices due to extramedullary hematopoiesis in primary myelofibrosis: a case report.
	Phillip V, Berger H, Straub M, Saugel B, Treiber M, Einwachter H, Schmid RM, Huber W. Onkologie. 2012;35(6):368-71.
	This report illustrates that TIPS placement can also be a promising treatment option in patients with primary myelofibrosis and portal hypertension due to extramedullary hematopoiesis.
20700988	FEMALE	Adult
	[Agnogenic myeloid metaplasia in pregnancy. Case report].
	Manole I, Costachescu G, Aldea MJ, Gavrilut M, Dumitrascu I. Rev Med Chir Soc Med Nat Iasi. 2010;114(2):465-9.
	Idiopathic myelofibrosis is a rare myeloproliferative disorder characterized by excessive accumulation of connective tissue in the bone marrow in association with anemia, splenomegaly and extramedullary hematopoiesis.
18850308	MALE
	Extramedullary peritoneal hematopoiesis combined with tuberculosis in a patient with primary myelofibrosis.
	Kim SJ, Lee Y, Kim SH, Kim H, Park KU, Bang SM, Lee JS. Med Oncol. 2009;26(2):238-41.
	Primary myelofibrosis (PMF) is a myeloproliferative disorder characterized by bone marrow fibrosis or dysmegakaryocytes, extramedullary hematopoiesis, and the presence of JAK2 mutations.
18705835	FEMALE
	Cutaneous extramedullary hematopoiesis in a patient with idiopathic myelofibrosis.
	Miyata T, Masuzawa M, Katsuoka K, Higashihara M. J Dermatol. 2008;35(7):456-61.
	Idiopathic myelofibrosis (IM) is a chronic myeloproliferative disorder and some cases of IM have extramedullary hematopoiesis.
18607123 (2627188)	MALE	Adult
	Intrahepatic extramedullary hematopoiesis mimicking a hypervascular hepatic neoplasm on dynamic- and SPIO-enhanced MRI.
	Lee IJ, Kim SH, Kim DS, Lee JM, Han JK, Choi BI. Korean J Radiol. 2008;9 Suppl:S34-8.
	We present a rare case of a focal intrahepatic extramedullary hematopoiesis (EMH) that mimicked a hypervascular hepatic neoplasm in a 33-year-old woman with idiopathic myelofibrosis.
18394406	FEMALE	Middle Aged
	[A case of cutaneous extramedullary hematopoiesis associated with idiopathic myelofibrosis].
	Corella F, Barnadas MA, Bordes R, Curell R, Espinosa I, Vergara C, Alomar A. Actas Dermosifiliogr. 2008;99(4):297-300.
	Cutaneous extramedullary hematopoiesis is a rare manifestation of chronic myeloproliferative processes, mainly chronic idiopathic myelofibrosis.
18394406	FEMALE	Middle Aged
	[A case of cutaneous extramedullary hematopoiesis associated with idiopathic myelofibrosis].
	Corella F, Barnadas MA, Bordes R, Curell R, Espinosa I, Vergara C, Alomar A. Actas Dermosifiliogr. 2008;99(4):297-300.
	We report a new case associated with chronic idiopathic myelofibrosis in which foci of cutaneous extramedullary hematopoiesis were observed 9 years after initial diagnosis.
18394406	FEMALE	Middle Aged
	[A case of cutaneous extramedullary hematopoiesis associated with idiopathic myelofibrosis].
	Corella F, Barnadas MA, Bordes R, Curell R, Espinosa I, Vergara C, Alomar A. Actas Dermosifiliogr. 2008;99(4):297-300.
	[A case of cutaneous extramedullary hematopoiesis associated with idiopathic myelofibrosis].
17762725	MALE	Middle Aged
	A meningioma with islets of extramedullary myeloid metaplasia: case report.
	Zona G, Spena G, Sbaffi PF, Spaziante R. Neurosurgery. 2007;61(2):E418-9; discussion E419.
	Extramedullary hematopoiesis within central nervous system primary tumors have already been reported but, to our knowledge, never before in a patient with evidence of idiopathic myelofibrosis.