Primary myelofibrosis

A rare myeloproliferative neoplasm characterized by stem-cell derived clonal over proliferation of mature myeloid lineages, such as erythrocytes, leukocytes, and megakaryocytes, with variable degrees of megakaryocyte atypia, associated with reticulin and/or collagen bone marrow fibrosis, osteosclerosis, ineffective erythropoiesis, angiogenesis, extramedullary hematopoiesis, and abnormal cytokine expression.

Esophageal varix

Extreme dilation of the submucusoal veins in the lower portion of the esophagus.

Total: 3

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PMID (PMCID)
20181038 (2830976)	OTHER
	Acute variceal bleeding in a patient with idiopathic myelofibrosis successfully treated with endoscopic variceal band ligation and chemotherapy: a case report.
	Tamaki K, Otaka M, Sakamoto N, Matsumoto K, Yamashina S, Watanabe S. J Med Case Rep. 2010;4:25.
	Gastrointestinal hemorrhages, which are due mostly to the rupture of the esophageal varices, have been sporadically reported to be an infrequent complication of idiopathic myelofibrosis.
3493936	MALE	Middle Aged
	Agnogenic myeloid metaplasia, portal hypertension, and sinusoidal abnormalities.
	Roux D, Merlio JP, Quinton A, Lamouliatte H, Balabaud C, Bioulac-Sage P. Gastroenterology. 1987;92(4):1067-72.
	A patient with agnogenic myeloid metaplasia suffered from gastrointestinal bleeding due to ruptured esophageal varices.
2984361	MALE
	Suppression of hepatic hematopoiesis with radioactive gold (198Au).
	Turner AR, Gummerman LW, Boggs DR. J Nucl Med. 1985;26(4):366-7.
	A patient with idiopathic myelofibrosis of some 20 yr duration developed esophageal varices and ascites.