Primary myelofibrosis

A rare myeloproliferative neoplasm characterized by stem-cell derived clonal over proliferation of mature myeloid lineages, such as erythrocytes, leukocytes, and megakaryocytes, with variable degrees of megakaryocyte atypia, associated with reticulin and/or collagen bone marrow fibrosis, osteosclerosis, ineffective erythropoiesis, angiogenesis, extramedullary hematopoiesis, and abnormal cytokine expression.

Headache

Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve.


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PMID (PMCID)
28603913
MALE
A common complication of myelofibrosis presenting as a rare finding in cerebrospinal fluid cytology.
Ruiz-Cordero R, Jorgensen JL, Krishnamurthy S, Landon G.
Diagn Cytopathol. 2017;45(11):1039-1041.
A 65 year-old man with a history of progressing primary myelofibrosis was admitted for headaches and right facial numbness.