Primary myelofibrosis

A rare myeloproliferative neoplasm characterized by stem-cell derived clonal over proliferation of mature myeloid lineages, such as erythrocytes, leukocytes, and megakaryocytes, with variable degrees of megakaryocyte atypia, associated with reticulin and/or collagen bone marrow fibrosis, osteosclerosis, ineffective erythropoiesis, angiogenesis, extramedullary hematopoiesis, and abnormal cytokine expression.

Bone pain

An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to bone.

Total: 2

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PMID (PMCID)
8727347	MALE
	[Primary myelofibrosis with severe bone pain].
	Kikukawa M, Arie Y, Kuramoto K, Tsutsumi H, Hirai M, Kumakawa T, Sawabe M, Mori M. Rinsho Ketsueki. 1996;37(3):228-32.
	[Primary myelofibrosis with severe bone pain].
3365931	MIXED_SAMPLE	Adult
	Hydroxyprolinuria and hypercalcaemia during immobilization in patients with idiopathic myelofibrosis.
	Baglin TP, Boughton BJ. Clin Lab Haematol. 1988;10(1):25-8.
	Two of three patients with bone pains and hydroxyprolinuria due to idiopathic myelofibrosis developed hypercalcaemia during periods of immobilization.