Primary myelofibrosis

A rare myeloproliferative neoplasm characterized by stem-cell derived clonal over proliferation of mature myeloid lineages, such as erythrocytes, leukocytes, and megakaryocytes, with variable degrees of megakaryocyte atypia, associated with reticulin and/or collagen bone marrow fibrosis, osteosclerosis, ineffective erythropoiesis, angiogenesis, extramedullary hematopoiesis, and abnormal cytokine expression.

Recurrent infections

Increased susceptibility to infections.

Total: 1

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PMID (PMCID)
23704469	FEMALE
	Low-dose ruxolitinib for improving leukopaenia and reducing recurrent infections associated with myelofibrosis.
	Islam R, Yellu MR, Rafiullah , Shaw GR. BMJ Case Rep. 2013;2013:.
	We report a case of primary myelofibrosis with marked improvement in leukopaenia and reduced recurrent infections, in addition to reduction in spleen size and improvement in disease-associated symptoms, within 20 weeks after using low-dose ruxolitinib.