Primary myelofibrosis

A rare myeloproliferative neoplasm characterized by stem-cell derived clonal over proliferation of mature myeloid lineages, such as erythrocytes, leukocytes, and megakaryocytes, with variable degrees of megakaryocyte atypia, associated with reticulin and/or collagen bone marrow fibrosis, osteosclerosis, ineffective erythropoiesis, angiogenesis, extramedullary hematopoiesis, and abnormal cytokine expression.

Myelodysplasia

Clonal hematopoietic stem cell disorders characterized by dysplasia (ineffective production) in one or more hematopoietic cell lineages, leading to anemia and cytopenia.

Total: 3

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PMID (PMCID)
22374528	MIXED_SAMPLE
	[Marked improvement of anemia during treatment with deferasirox in patients with primary myelofibrosis and acute myeloid leukemia with myelodysplasia-related changes].
	Matsuki E, Matsumoto K, Nakaya A, Yamane A, Kato J, Okamoto S. Rinsho Ketsueki. 2012;53(1):78-82.
	[Marked improvement of anemia during treatment with deferasirox in patients with primary myelofibrosis and acute myeloid leukemia with myelodysplasia-related changes].
16364769	MIXED_SAMPLE	Adult
	Cryptic 6p21.3 duplications and triplication involving HMGA1 partially masked by add 6p in four cases of myelodysplasia.
	Andrieux J, Geffroy S, Bilhou-Nabera C, Dupriez B, Demory JL, Bauters F, Lai JL, Dastugue N. Cancer Genet Cytogenet. 2006;164(1):84-7.
	High-mobility group AT-hook 2 (HMGA2) rearrangements have been described in myelofibrosis with myeloid metaplasia (MMM) and also in myelodysplasia.
8285020	MIXED_SAMPLE	Adult
	Recombinant human erythropoietin in patients with myelodysplastic syndrome and myelofibrosis.
	Mohr B, Herrmann R, Huhn D. Acta Haematol. 1993;90(2):65-70.
	In a dose titration study we tested the efficacy and tolerance of recombinant human erythropoietin (rhEPO) in 10 patients with myelodysplasia (MDS) and 2 patients with idiopathic myelofibrosis.