Primary myelofibrosis

A rare myeloproliferative neoplasm characterized by stem-cell derived clonal over proliferation of mature myeloid lineages, such as erythrocytes, leukocytes, and megakaryocytes, with variable degrees of megakaryocyte atypia, associated with reticulin and/or collagen bone marrow fibrosis, osteosclerosis, ineffective erythropoiesis, angiogenesis, extramedullary hematopoiesis, and abnormal cytokine expression.

Hypercalcemia

An abnormally increased calcium concentration in the blood.


Total: 3

                       


(per page)
PMID (PMCID)
22730513
 FEMALE Middle Aged
Resorptive hypercalcemia in post-essential thrombocythemia myelofibrosis: treatment with denosumab.
Khoury N, Chang J, Gru AA, Whyte MP.
J Clin Endocrinol Metab. 2012;97(9):3051-5.
Her disturbance in calcium homeostasis was not PTH- or vitamin D-mediated, although this has been postulated in cases of hypercalcemia with the related entity of primary myelofibrosis.
10593353
 MALE Middle Aged
Hypercalcemia complicating leukemic transformation of agnogenic myeloid metaplasia-myelofibrosis.
Kumar S, Mow BM, Kaufmann SH.
Mayo Clin Proc. 1999;74(12):1233-7.
We describe a patient who developed hypercalcemia in association with transformation of agnogenic myeloid metaplasia into M7 acute myelogenous leukemia.
1546720
 MALE Adult
Hypercalcemia in idiopathic myelofibrosis: modulation of calcium and collagen homeostasis by 1,25-dihydroxyvitamin D3.
Voss A, Schmidt K, Hasselbalch H, Junker P.
Am J Hematol. 1992;39(3):231-3.
A case of idiopathic myelofibrosis (IMF) presenting with hypercalcemia and hypercalcitriolemia is reported.