Primary myelofibrosis

A rare myeloproliferative neoplasm characterized by stem-cell derived clonal over proliferation of mature myeloid lineages, such as erythrocytes, leukocytes, and megakaryocytes, with variable degrees of megakaryocyte atypia, associated with reticulin and/or collagen bone marrow fibrosis, osteosclerosis, ineffective erythropoiesis, angiogenesis, extramedullary hematopoiesis, and abnormal cytokine expression.

Elliptocytosis

The presence of elliptical, cigar-shaped erythrocytes on peripheral blood smear.


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PMID (PMCID)
27734802
MALE Middle Aged
An usual cause of elliptocytosis.
Broseus J, Roth-Guepin G, D'Aveni-Piney M, Perrot A, Lesesve JF, Perrin J.
Ann Biol Clin (Paris). 2016;74(6):704-707.
The objectification of elliptocytosis accompanied by splenomegaly, a collagen myelofibrosis and the presence of the mutation JAK2V617F allowed the diagnosis of primary myelofibrosis with atypical initial presentation.