Primary myelofibrosis

A rare myeloproliferative neoplasm characterized by stem-cell derived clonal over proliferation of mature myeloid lineages, such as erythrocytes, leukocytes, and megakaryocytes, with variable degrees of megakaryocyte atypia, associated with reticulin and/or collagen bone marrow fibrosis, osteosclerosis, ineffective erythropoiesis, angiogenesis, extramedullary hematopoiesis, and abnormal cytokine expression.

Venous thrombosis

Formation of a blood clot (thrombus) inside a vein, causing the obstruction of blood flow.

Total: 4

(per page)

PMID (PMCID)
28991281	MIXED_SAMPLE	Middle Aged
	Splanchnic vein thrombosis as a first manifestation of Primary myelofibrosis
	Campos-Cabrera G, Campos-Cabrera V, Campos-Cabrera S, Campos-Villagomez JL, Romero-Gonzalez A. Gac Med Mex. 2017;153(4):537-540.
	In this study 11 cases of primary myelofibrosis (PM) were evaluated and 2 debuted with splanchnic venous thrombosis (SVT); so after seeing the results of this study and of world literature, it is suggested that in patients with SVT, diagnostic methods for PM like the JAK2V617F mutation should be included.
27693837 (5045565)	OTHER
	Massive upper gastrointestinal bleeding due to splenoportal axis thrombosis in a patient with a tested JAK2 mutation: A case report and review literature.
	Macias I. Int J Surg Case Rep. 2016;28:93-96.
	The primary myeloproliferative disorders are the main cause of portal venous thrombosis and somatic mutation of Janus Kinase 2 gene (JAK2 V617F) can be found in approximately 90% of polycythemia vera, 50% of essential thrombocyrosis and 50% primary myelofibrosis.
3125672	FEMALE
	Histological study of intrahepatic cavernous transformation in a patient with primary myelofibrosis and portal venous thrombosis.
	Terada T, Takegoshi T, Doishita K, Nakanuma Y. Virchows Arch A Pathol Anat Histopathol. 1988;412(4):339-45.
	Histological study of intrahepatic cavernous transformation in a patient with primary myelofibrosis and portal venous thrombosis.
3125672	FEMALE
	Histological study of intrahepatic cavernous transformation in a patient with primary myelofibrosis and portal venous thrombosis.
	Terada T, Takegoshi T, Doishita K, Nakanuma Y. Virchows Arch A Pathol Anat Histopathol. 1988;412(4):339-45.
	Cavernous transformation in the liver was examined histologically by serial section observations, in an autopsy case of portal venous thrombosis and primary myelofibrosis.