Primary myelofibrosis

A rare myeloproliferative neoplasm characterized by stem-cell derived clonal over proliferation of mature myeloid lineages, such as erythrocytes, leukocytes, and megakaryocytes, with variable degrees of megakaryocyte atypia, associated with reticulin and/or collagen bone marrow fibrosis, osteosclerosis, ineffective erythropoiesis, angiogenesis, extramedullary hematopoiesis, and abnormal cytokine expression.

Lymphoproliferative disorder



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PMID (PMCID)
3412746
 MALE Adult
Evolution of malignant lymphoma in agnogenic myeloid metaplasia.
Yinnon A, Kopolovic J, Dollberg L, Hershko C.
Oncology. 1988;45(5):373-7.
These observations demonstrate the close relation between myeloproliferative and lymphoproliferative syndromes and illustrate the diversity of malignant lymphoproliferative disorders into which agnogenic myeloid metaplasia may evolve in the course of disease.