Primary myelofibrosis

A rare myeloproliferative neoplasm characterized by stem-cell derived clonal over proliferation of mature myeloid lineages, such as erythrocytes, leukocytes, and megakaryocytes, with variable degrees of megakaryocyte atypia, associated with reticulin and/or collagen bone marrow fibrosis, osteosclerosis, ineffective erythropoiesis, angiogenesis, extramedullary hematopoiesis, and abnormal cytokine expression.

Plasmacytosis

An abnormally increased number of plasma cells in tissues, exudates, or blood


Total: 1

                      


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PMID (PMCID)
4036981
MIXED_SAMPLE Middle Aged
Plasma cell dyscrasia with marrow fibrosis. Clinicopathologic syndrome.
Vandermolen L, Rice L, Lynch EC.
Am J Med. 1985;79(3):297-302.
This syndrome was characterized by significant paraprotein levels, marked marrow fibrosis, and plasmacytosis, without features of extramedullary hematopoiesis (agnogenic myeloid metaplasia) and leukoerythroblastosis.