Primary myelofibrosis

A rare myeloproliferative neoplasm characterized by stem-cell derived clonal over proliferation of mature myeloid lineages, such as erythrocytes, leukocytes, and megakaryocytes, with variable degrees of megakaryocyte atypia, associated with reticulin and/or collagen bone marrow fibrosis, osteosclerosis, ineffective erythropoiesis, angiogenesis, extramedullary hematopoiesis, and abnormal cytokine expression.

Erythromelalgia

Recurrent episodes of redness, burning pain, and warmth of the extremities following exposure to heat or exercise with symptoms predominantly involving the feet.

Total: 2

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PMID (PMCID)
1550104	MIXED_SAMPLE	Adult
	Erythromelalgia in thrombocythemia of various myeloproliferative disorders.
	Michiels JJ, ten Kate FJ. Am J Hematol. 1992;39(2):131-6.
	Here we extend observations on the occurrence of erythromelalgia in thrombocythemia associated with primary myelofibrosis, Philadelphia-chromosome positive micromegakaryocytic myelofibrosis, and myelodysplastic syndrome type II.
2779694	MIXED_SAMPLE	Adult
	Thrombocythaemic erythromelalgia in chronic myeloproliferative and myelodysplastic disorders.
	Michiels JJ, Hagemeyer A, Prins ME. Neth J Med. 1989;35(1-2):4-10.
	Erythromelalgia, which is specific for primary thrombocythaemia or polycythaemia with thrombocythaemia, is reported in a case of primary myelofibrosis at platelet counts of between 350 and 450 X 10(9)/l.