Primary myelofibrosis

A rare myeloproliferative neoplasm characterized by stem-cell derived clonal over proliferation of mature myeloid lineages, such as erythrocytes, leukocytes, and megakaryocytes, with variable degrees of megakaryocyte atypia, associated with reticulin and/or collagen bone marrow fibrosis, osteosclerosis, ineffective erythropoiesis, angiogenesis, extramedullary hematopoiesis, and abnormal cytokine expression.

Skin nodule

Morphologically similar to a papule, but greater than either 10mm in both width and depth, and most frequently centered in the dermis or subcutaneous fat.

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PMID (PMCID)
2313911	FEMALE
	[Blastic crisis of primary myelofibrosis associated with multiple myeloblastomas ].
	Fukushima T, Uchida M, Iwasaki H, Kamiya K, Tanaka T, Yoshimura T, Sasaki K, Tsutani H, Wano Y, Takayama H, et al.. Rinsho Ketsueki. 1990;31(1):95-9.
	Histological examination of the skin nodules revealed that they were myeloblastomas, thus suggesting leukemic transformation of primary myelofibrosis.