Alpha-thalassemia

An inherited hemoglobinopathy characterized by impaired synthesis of alpha-globin chains leading to a variable clinical picture depending on the number of affected alleles.

Splenomegaly

Abnormal increased size of the spleen.


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PMID (PMCID)
8969620
 MALE Adult
Case report: splenomegaly and splenic sequestration in an adult with sickle cell anemia.
Moll S, Orringer EP.
Am J Med Sci. 1996;312(6):299-302.
It appears that high hemoglobin F (HbF) levels and alpha-thalassemia may be important etiologic factors in causing persistence of splenomegaly and predisposing patients to splenic sequestration crises.