Beta-thalassemia

Beta-thalassemia (BT) is characterized by deficiency (Beta+) or absence (Beta0) of synthesis of the beta globin chains of hemoglobin (Hb).

Hypochromic anemia

A type of anemia characterized by an abnormally low concentration of hemoglobin in the erythrocytes.


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PMID (PMCID)
15658193
 MIXED_SAMPLE
Hb Dhonburi (Neapolis) [beta126(H4)Val-->Gly] identified in a family from northern Iran.
Moghimi B, Yavarian M, Oberkanins C, Amini SS, Khatami S, Rouhi S, Kahrizi K, Najmabadi H.
Hemoglobin. 2004;28(4):353-6.
The majority of patients suffer from beta-thalassemia (thal), but cases with microcytic hypochromic anemia and normal electrophoretic patterns are suspected to have alpha- or silent beta-thal.
9056561
 FEMALE Middle Aged
Molecular basis of asymptomatic beta-thalassemia major in an African American individual.
Ballas SK, Cai SP, Gabuzda T, Chehab FF.
Am J Med Genet. 1997;69(2):196-9.
Heterozygous beta-thalassemia is typically characterized by a mild microcytic hypochromic anemia without any significant clinical implications.
677120
 MALE Child
beta-Thalassemia arising as a new mutation in an American child.
Nronha PA, Honig GR.
Am J Hematol. 1978;4(2):187-92.
A 6-year-old child of northern European ancestry was found to have microcytic, hypochromic anemia with an elevated level of hemoglobin A2 and an unbalanced pattern of globin chain synthesis characteristic of beta-thalassemia trait.