Beta-thalassemia

Beta-thalassemia (BT) is characterized by deficiency (Beta+) or absence (Beta0) of synthesis of the beta globin chains of hemoglobin (Hb).

Microcytic anemia

A kind of anemia in which the volume of the red blood cells is reduced.


Total: 2

                       


(per page)
PMID (PMCID)
2434529
 FEMALE Child
Hemoglobin Mississippi (beta 44ser----cys). Studies of the thalassemic phenotype in a mixed heterozygote with beta +-thalassemia.
Steinberg MH, Adams JG 3rd, Morrison WT, Pullen DJ, Abney R, Ibrahim A, Rieder RF.
J Clin Invest. 1987;79(3):826-32.
While heterozygotes for HbMS are clinically and hematologically normal and carriers of the beta +-thalassemia gene in our family had mild microcytic anemia, the proband with HbMS-beta +-thalassemia had a hemoglobin level of 7 g/dl, mean corpuscular volume (MCV) of 68 fl, reticulocytes of 2-6%, HbF of 18%, marked anisocytosis and poikilocytosis, and splenomegaly, all features of thalassemia intermedia.
2434529
 FEMALE Child
Hemoglobin Mississippi (beta 44ser----cys). Studies of the thalassemic phenotype in a mixed heterozygote with beta +-thalassemia.
Steinberg MH, Adams JG 3rd, Morrison WT, Pullen DJ, Abney R, Ibrahim A, Rieder RF.
J Clin Invest. 1987;79(3):826-32.
While heterozygotes for HbMS are clinically and hematologically normal and carriers of the beta +-thalassemia gene in our family had mild microcytic anemia, the proband with HbMS-beta +-thalassemia had a hemoglobin level of 7 g/dl, mean corpuscular volume (MCV) of 68 fl, reticulocytes of 2-6%, HbF of 18%, marked anisocytosis and poikilocytosis, and splenomegaly, all features of thalassemia intermedia.