Total: 2 |
|
PMID (PMCID) | ||
---|---|---|
2434529 |
FEMALE | Child |
Hemoglobin Mississippi (beta 44ser----cys). Studies of the thalassemic phenotype in a mixed heterozygote with beta +-thalassemia. | ||
Steinberg MH, Adams JG 3rd, Morrison WT, Pullen DJ, Abney R, Ibrahim A, Rieder RF. J Clin Invest. 1987;79(3):826-32. |
||
While heterozygotes for HbMS are clinically and hematologically normal and carriers of the beta +-thalassemia gene in our family had mild microcytic anemia, the proband with HbMS-beta +-thalassemia had a hemoglobin level of 7 g/dl, mean corpuscular volume (MCV) of 68 fl, reticulocytes of 2-6%, HbF of 18%, marked anisocytosis and poikilocytosis, and splenomegaly, all features of thalassemia intermedia. | ||
2434529 |
FEMALE | Child |
Hemoglobin Mississippi (beta 44ser----cys). Studies of the thalassemic phenotype in a mixed heterozygote with beta +-thalassemia. | ||
Steinberg MH, Adams JG 3rd, Morrison WT, Pullen DJ, Abney R, Ibrahim A, Rieder RF. J Clin Invest. 1987;79(3):826-32. |
||
While heterozygotes for HbMS are clinically and hematologically normal and carriers of the beta +-thalassemia gene in our family had mild microcytic anemia, the proband with HbMS-beta +-thalassemia had a hemoglobin level of 7 g/dl, mean corpuscular volume (MCV) of 68 fl, reticulocytes of 2-6%, HbF of 18%, marked anisocytosis and poikilocytosis, and splenomegaly, all features of thalassemia intermedia. |