Beta-thalassemia

Beta-thalassemia (BT) is characterized by deficiency (Beta+) or absence (Beta0) of synthesis of the beta globin chains of hemoglobin (Hb).

Heinz bodies

A type of erythrocyte inclusion composed of denatured hemoglobin.


Total: 2

                       


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PMID (PMCID)
8037185
 MIXED_SAMPLE Infant
Beta-thalassemia alleles and unstable hemoglobin types among Russian pediatric patients.
Curuk MA, Molchanova TP, Postnikov YuV , Pobedimskaya DD, Liang R, Baysal E, Kolodey S, Smetanina NS, Tokarev YuN , Rumyantsev AG, et al..
Am J Hematol. 1994;46(4):329-32.
This condition and two new variants have the characteristics of a dominant type of beta-thalassemia heterozygosity with moderate anemia, Heinz body formation, splenomegaly, etc.
7693620
 FEMALE Adult
Hb Hradec Kralove (Hb HK) or alpha 2 beta 2 115(G17)Ala-->Asp, a severely unstable hemoglobin variant resulting in a dominant beta-thalassemia trait in a Czech family.
Divoky V, Svobodova M, Indrak K, Chrobak L, Molchanova TP, Huisman TH.
Hemoglobin. 1993;17(4):319-28.
Its presence results in a dominant type of beta-thalassemia in the two heterozygotes, with moderate anemia, reticulocytosis, nucleated red cells, target cells, and other red cell changes, Heinz body formation, and splenomegaly; the oldest of the two patients was splenectomized.