Beta-thalassemia

Beta-thalassemia (BT) is characterized by deficiency (Beta+) or absence (Beta0) of synthesis of the beta globin chains of hemoglobin (Hb).

Hypochromia

A qualitative impression that red blood cells have less color than normal when examined under a microscope, usually related to a reduced amount of hemoglobin in the red blood cells.


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PMID (PMCID)
10695401
 MALE Middle Aged
[beta-thalassemia minor diagnosed in a patient with chronic myelogenous leukemia during hydroxyurea therapy].
Chiba K, Kurosawa M, Kondo T, Suzuki S, Musashi M, Asaka M, Imamura M, Hattori Y, Oba Y.
Rinsho Ketsueki. 2000;41(1):61-4.
A 55-year-old man was admitted to our hospital because of leukocytosis and microcytic anemia with hypochromia, target cells, and increased levels of hemoglobin A2 and hemoglobin F. The results of a gene analysis yielded a diagnosis of chronic myelogenous leukemia and beta-thalassemia minor.
6166632
 MALE
Molecular analysis of the beta-thalassemia phenotype associated with inheritance of hemoglobin E (alpha 2 beta2(26)Glu leads to Lys).
Benz EJ Jr, Berman BW, Tonkonow BL, Coupal E, Coates T, Boxer LA, Altman A, Adams JG 3rd.
J Clin Invest. 1981;68(1):118-26.
Inheritance of the gene for betaE-globin is associated with hypochromia and microcytosis, reminiscent of typical heterozygous beta-thalassemia.
543507
 FEMALE
The quiet carrier of beta-thalassemia.
Kelleher JF Jr, Schwartz E.
Am J Pediatr Hematol Oncol. 1979;1(1):15-7.
Heterozygosity for beta-thalassemia is usually characterized by hypochromia, microcytosis, mild anemia, and increased percentage of Hb A2, and normal or mildly increased Hb F. We have studied an unusual type of beta-thalassemia with typical morphologic abnormalities but normal levels of Hb A2 and Hb F, with diagnosis confirmed by globin synthesis studies.
543507
 FEMALE
The quiet carrier of beta-thalassemia.
Kelleher JF Jr, Schwartz E.
Am J Pediatr Hematol Oncol. 1979;1(1):15-7.
Heterozygosity for beta-thalassemia is usually characterized by hypochromia, microcytosis, mild anemia, and increased percentage of Hb A2, and normal or mildly increased Hb F. We have studied an unusual type of beta-thalassemia with typical morphologic abnormalities but normal levels of Hb A2 and Hb F, with diagnosis confirmed by globin synthesis studies.